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Ristocetin A sulfate (CAS 11140-99-1)

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Alternate Names:
Ristocetin •sulfate, Ristomycin III•sulfate
Application:
Ristocetin A sulfate is an antibiotic with platelet aggregation activity
CAS Number:
11140-99-1
Purity:
>95%
Molecular Weight:
2165.90
Molecular Formula:
C95H110N8O44•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ristocetin A sulfate functions as an antibiotic. It acts by binding to a specific site on the bacterial cell wall, disrupting the formation of the bacterial cell membrane. This interference ultimately leads to the inhibition of bacterial growth and reproduction. Ristocetin A sulfate achieves this by interacting with the von Willebrand factor and platelet glycoprotein Ib-IX-V complex, which is involved in platelet adhesion and aggregation. This interaction results in the activation of the glycoprotein complex, leading to the agglutination of platelets and the inhibition of bacterial growth. In this way, Ristocetin A sulfate may play a role in studying bacterial cell wall synthesis and platelet function in experimental applications.


Ristocetin A sulfate (CAS 11140-99-1) References

  1. Chiral separations using the macrocyclic antibiotics: a review.  |  Ward, TJ. and Farris, AB. 2001. J Chromatogr A. 906: 73-89. PMID: 11215904
  2. Practical synthesis of a tetrasaccharide derivative corresponding to ristomycin A and ristocetin A.  |  Zhang, M., et al. 2001. Carbohydr Res. 330: 319-24. PMID: 11270810
  3. Synergistic chiral separations using the glycopeptides ristocetin A and vancomycin.  |  Ward, TJ., et al. 2001. J Biochem Biophys Methods. 48: 163-74. PMID: 11356486
  4. Ristocetin: a clinical trial.  |  VAN ROOYEN, CE., et al. 1958. Can Med Assoc J. 79: 723-5. PMID: 13585306
  5. HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review.  |  Ilisz, I., et al. 2006. J Sep Sci. 29: 1305-21. PMID: 16894775
  6. Structure of ristocetin A in complex with a bacterial cell-wall mimetic.  |  Nahoum, V., et al. 2009. Acta Crystallogr D Biol Crystallogr. 65: 832-8. PMID: 19622867
  7. Ristocetin--a new tool in the investigation of platelet aggregation.  |  Howard, MA. and Firkin, BG. 1971. Thromb Diath Haemorrh. 26: 362-9. PMID: 5316292
  8. Destruction of the platelet aggregating activity of ristocetin A.  |  Kuwahara, S. and Chambers, WT. 1978. Experientia. 34: 532-4. PMID: 565300
  9. Comparison and modeling study of vancomycin, ristocetin A, and teicoplanin for CE enantioseparations.  |  Gasper, MP., et al. 1996. Anal Chem. 68: 2501-14. PMID: 8694258
  10. Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction.  |  Cho, YR., et al. 1996. Chem Biol. 3: 207-15. PMID: 8807847

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ristocetin A sulfate, 10 mg

sc-202318
10 mg
$319.00

Ristocetin A sulfate, 100 mg

sc-202318A
100 mg
$728.00

Ristocetin A sulfate, 1 g

sc-202318B
1 g
$4682.00