RGS3 Antibody (CC-Q7): sc-100762

RGS3 Antibody (CC-Q7) is a mouse monoclonal IgG1 kappa light chain antibody that detects RGS3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RGS3 antibody (CC-Q7) is available as the non-conjugated form. RGS3 plays a crucial role in the regulation of G protein signaling pathways, which are essential for transmitting signals from cell surface receptors to various intracellular effectors. Specifically, RGS3 interacts with the activated form of Gα11, a member of the heterotrimeric G protein family. This interaction enhances the GTPase activity of Gα11, leading to its inactivation and a subsequent decrease in intracellular calcium levels, which is vital for numerous cellular processes, including muscle contraction and neurotransmitter release. RGS3 is predominantly expressed in adult kidney and myocardium, where RGS3 is primarily localized in the cytoplasm. Upon activation of Gα11, RGS3 translocates to the plasma membrane, positioning RGS3 strategically to modulate G protein signaling effectively. This dynamic localization and interaction underscore RGS3′s importance in maintaining cellular homeostasis and responding to extracellular signals.

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RGS3 Antibody (CC-Q7) References:

1. Modulation of renal tubular cell function by RGS3.  |  Grüning, W., et al. 1999. Am J Physiol. 276: F535-43. PMID: 10198412
2. A G-protein signaling network mediated by an RGS protein.  |  Guan, KL. and Han, M. 1999. Genes Dev. 13: 1763-7. PMID: 10421628
3. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
4. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.  |  Druey, KM., et al. 1996. Nature. 379: 742-6. PMID: 8602223
5. A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C.  |  Chatterjee, TK., et al. 1997. J Biol Chem. 272: 15481-7. PMID: 9182581
6. Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene.  |  Chatterjee, TK., et al. 1997. Genomics. 45: 429-33. PMID: 9344672
7. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.  |  Dulin, NO., et al. 1999. Mol Cell Biol. 19: 714-23. PMID: 9858594

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGS3 Antibody (CC-Q7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RGS3 Antibody (CC-Q7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGS3 Antibody (CC-Q7) Specifications

Alternate Product Name: RGS3

Product Clone Name: CC-Q7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-193

Epitope Target: RGS3

Epitope Species: human

Product Reactivity/Detection: RGS3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RGS3 Antibody (CC-Q7): N/A