RARβ/Retinoic Acid Receptor β Antibody (336): sc-56864

RARβ Antibody (336) is a mouse monoclonal IgG1 antibody raised against a human-derived RARβ peptide, capable of detecting RARβ (clone 336) in mouse, rat, and human samples by western blotting (WB). Retinoic Acid Receptor Beta (RARβ), also known as NR1B2, is a nuclear receptor that mediates the biological effects of retinoic acid, a metabolite of vitamin A essential for vertebrate development and tissue differentiation. RARβ functions as a transcription factor regulating gene expression involved in cell proliferation, differentiation, and apoptosis, making RARβ crucial for maintaining normal cellular functions. RARβ exists in multiple isoforms, including RARβ1 and RARβ2, generated through alternative splicing. RARβ2, in particular, has been implicated as a tumor suppressor due to its role in inducing apoptosis. Loss or reduced expression of RARβ, especially RARβ2, has been observed in various cancers such as breast, lung, and oral cancers, suggesting RARβ′s importance in preventing carcinogenesis. By providing reliable detection of RARβ, anti-RARβ antibody (336) aids research focusing on retinoid signaling pathways, cancer development, and potential therapeutic interventions targeting RARβ-mediated pathways.

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RARβ/Retinoic Acid Receptor β Antibody (336) References:

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The preferred RARβ/Retinoic Acid Receptor β antibody is RARβ/Retinoic Acid Receptor β Antibody (B-12): sc-514585.