Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RARβ Antibody (336) is a high quality monoclonal RAR beta antibody (also designated RARβ antibody) suitable for the detection of the RAR beta protein of mouse, rat and human origin. RARβ Antibody (336) is available as the non-conjugated anti-RAR beta antibody. Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families and thus modulate the effects of RA on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARα, RARβ and RARγ, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The human RARβ gene maps to chromosome 3p25-p21 and encodes two isoforms, RARβ1 and RARβ2. The RARβ2 isoform may act as a tumor suppressor gene by inducing apoptosis. This role for RARβ2 may explain the chemopreventive and therapeutic effects of retinoids. RARβ2 expression is diminished or lost completely during breast cancer progression. RARβ expression also decreases in over 50 percent of oral and lung premalignant lesions; loss of RARβ expression may contribute to carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.