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Ranatensin (CAS 29451-71-6)

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Application:
Ranatensin is a frog skin peptide that interferes with nociception
CAS Number:
29451-71-6
Molecular Weight:
1281.5
Molecular Formula:
C61H85N16O13S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ranatensin, a peptide originally isolated from the skin of certain frog species, has garnered significant interest in scientific research for its potential as a pharmacological tool and its implications in various physiological processes. One area of investigation involves exploring the mechanisms of action of ranatensin on the cardiovascular system. Research has demonstrated that ranatensin acts as an agonist for specific receptors, including the angiotensin II type 2 (AT2) receptor, exerting vasodilatory effects and modulating blood pressure regulation. Furthermore, studies have delved into the molecular interactions between ranatensin and its receptor targets, elucidating its role in intracellular signaling pathways and downstream cellular responses. Moreover, ranatensin has been utilized as a molecular probe in studies investigating the structure-activity relationships of peptide-receptor interactions. Additionally, research efforts have explored the potential neuroendocrine and behavioral effects of ranatensin, shedding light on its broader physiological functions beyond cardiovascular regulation. Overall, ranatensin serves as a valuable tool for studying peptide-receptor interactions and unraveling the complex mechanisms underlying cardiovascular physiology, offering insights into potential interventions for cardiovascular diseases.


Ranatensin (CAS 29451-71-6) References

  1. The Role of a Natural Amphibian Skin-Based Peptide, Ranatensin, in Pancreatic Cancers Expressing Dopamine D2 Receptors.  |  Laskowska, AK., et al. 2022. Cancers (Basel). 14: PMID: 36428628
  2. Evaluation of Antimicrobial Activities against Various E. coli Strains of a Novel Hybrid Peptide-LENART01.  |  Serafin, P., et al. 2023. Molecules. 28: PMID: 37446618
  3. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals.  |  Geller, RG., et al. 1970. Br J Pharmacol. 40: 605-16. PMID: 4322040
  4. Effects of ranatensin, a polypeptide from frog skin, on isolated smooth muscle.  |  Clineschmidt, BV., et al. 1971. Br J Pharmacol. 41: 622-8. PMID: 4325450
  5. The relationship between the vascular responses to the peptides ranatensin and angiotensin.  |  Louis, WJ., et al. 1971. Eur J Pharmacol. 14: 340-3. PMID: 4333701
  6. Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P.  |  Modlin, IM., et al. 1981. Regul Pept. 1: 279-88. PMID: 6166964
  7. Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats.  |  de Caro, G., et al. 1984. Peptides. 5: 607-13. PMID: 6473174
  8. Stimulatory effects of bombesin-like peptides on hypothalamic arcuate neurons in rat brain slices.  |  Lin, JY. and Pan, JT. 1994. Brain Res Bull. 35: 241-6. PMID: 7812804
  9. Effects of bombesin family peptides and antagonists on guinea pig nasal mucosal secretion.  |  Ali, M., et al. 1996. J Pharmacol Exp Ther. 276: 1266-71. PMID: 8786559

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ranatensin, 1 mg

sc-391167
1 mg
$106.00

Ranatensin, 5 mg

sc-391167A
5 mg
$316.00