Ral GPS2 Antibody (FE-63): sc-81899

Ral GPS2 Antibody (FE-63) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Ral GPS2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Ral GPS2 antibody (FE-63) is available as the non-conjugated monoclonal isotype antibody. Ral GPS2, or Ral GEF with PH domain and SH3 binding motif 2, is a 583 amino acid protein that serves as a guanine nucleotide-exchange factor (GEF) specifically for the small GTPase Ral A. Notably, Ral GPS2 is distinct from other Ral GEFs due to its lack of a Ras-GTP-binding domain, allowing activation in a Ras-independent manner. This protein is primarily expressed in the testis and brain, where Ral GPS2 localizes to the cytoplasm and features one Ras-GEF domain and one pleckstrin homology (PH) domain. The PH domain enables Ral GPS2 to associate with the cell membrane and bind to phosphatidylinositol 4,5-bisphosphate, which is crucial for various signaling pathways. Furthermore, Ral GPS2 interacts with proteins such as GRB2 and phospholipase C gamma 1 (PLC γ1), suggesting a role in cytoskeleton organization and the Ras-independent stimulation of transcription. Mutations in the gene encoding Ral GPS2 have been implicated in the development of Alzheimer′s disease, highlighting potential relevance in neurodegenerative disorders.

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Ral GPS2 Antibody (FE-63) References:

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