RABAPTIN-5 Antibody (B-8): sc-271069
- RABAPTIN-5 Antibody (B-8) is a mouse monoclonal IgG1 κ RABAPTIN-5 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against a peptide mapping C-terminus (h) of RABAPTIN-5 of human origin
- RABAPTIN-5 Antibody (B-8) is recommended for detection of RABAPTIN-5 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and avian
- Anti-RABAPTIN-5 Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of RABAPTIN-5 (B-8): sc-271069.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RABAPTIN-5 Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with RABAPTIN-5 Antibody (B-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
RABAPTIN-5 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects RABAPTIN-5 of mouse, rat, human, and avian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RABAPTIN-5 antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RABAPTIN-5 plays a crucial role in the endocytic pathway, particularly in the regulation of early endosome fusion. RABAPTIN-5 acts as a downstream effector of Rab5, a key regulator of endocytic transport, which is localized to the plasma membrane, clathrin-coated pits, and early endosomes. RABAPTIN-5 interaction with Rab5 is essential for the membrane docking and fusion processes that facilitate the transport of materials within the cell. Immunodepletion of RABAPTIN-5 has been shown to significantly inhibit Rab5-dependent early endosome fusion, highlighting RABAPTIN-5′s importance in maintaining cellular transport mechanisms. RABAPTIN-5 monoclonal antibody (B-8) enables researchers to gain valuable insights into the dynamics of endocytosis and the functional roles of Rab proteins in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RABAPTIN-5 Antibody (B-8) References:
- GTP-binding proteins in intracellular transport. | Pfeffer, SR. 1992. Trends Cell Biol. 2: 41-6. PMID: 14731525
- Cloning of a Rab3 isotype predominantly expressed in adipocytes. | Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
- The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. | Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
- Coatomers and SNAREs in promoting membrane traffic. | Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
- Friends and family: the role of the Rab GTPases in vesicular traffic. | Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
- The role of GTP-binding proteins in transport along the exocytic pathway. | Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
- Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation. | Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
- Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. | Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066
- Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. | Stenmark, H., et al. 1995. Cell. 83: 423-32. PMID: 8521472
- GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. | Rybin, V., et al. 1996. Nature. 383: 266-9. PMID: 8805704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RABAPTIN-5 Antibody (B-8) | sc-271069 | 200 µg/ml | $316.00 | |||
RABAPTIN-5 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-529115 | 200 µg Ab; 10 µg BP | $354.00 | |||
RABAPTIN-5 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-521840 | 200 µg Ab, 40 µg BP | $354.00 | |||
RABAPTIN-5 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-543328 | 200 µg Ab; 20 µg BP | $354.00 | |||
RABAPTIN-5 Antibody (B-8) AC | sc-271069 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RABAPTIN-5 Antibody (B-8) HRP | sc-271069 HRP | 200 µg/ml | $316.00 | |||
RABAPTIN-5 Antibody (B-8) FITC | sc-271069 FITC | 200 µg/ml | $330.00 | |||
RABAPTIN-5 Antibody (B-8) PE | sc-271069 PE | 200 µg/ml | $343.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 488 | sc-271069 AF488 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 546 | sc-271069 AF546 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 594 | sc-271069 AF594 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 647 | sc-271069 AF647 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 680 | sc-271069 AF680 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 Antibody (B-8) Alexa Fluor® 790 | sc-271069 AF790 | 200 µg/ml | $357.00 | |||
RABAPTIN-5 (B-8) Neutralizing Peptide | sc-271069 P | 100 µg/0.5 ml | $68.00 |