Rab 8A Antibody (826B2Q) is a mouse monoclonal IgG1 antibody that detects Rab 8A in mouse, rat, and human samples through western blotting (WB). Rab 8A is a member of the Rab family of small GTPases, which play a crucial role in intracellular membrane trafficking. Specifically, Rab 8A is involved in the regulation of vesicle transport from the trans-Golgi network to the plasma membrane, a process essential for maintaining cellular homeostasis and facilitating the secretion of proteins and lipids. The proper functioning of Rab 8A is vital for various cellular processes, including the delivery of membrane proteins and the recycling of receptors, which are critical for signal transduction and cellular communication. Dysregulation of Rab 8A has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting Rab 8A′s importance as a potential therapeutic target. Anti-Rab 8A antibody (826B2Q) serves as an invaluable tool for researchers studying the dynamics of membrane trafficking and the role of Rab proteins in health and disease.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rab 8A Antibody (826B2Q) References:
- Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. | Sato, T., et al. 2014. J Cell Sci. 127: 422-31. PMID: 24213529
- Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells. | Sun, Y., et al. 2014. Mol Biol Cell. 25: 1159-70. PMID: 24478457
- Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts. | Li, H., et al. 2017. FEBS Lett. 591: 491-499. PMID: 28079283
- Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors. | Wall, AA., et al. 2017. J Biol Chem. 292: 4411-4422. PMID: 28130450
- LRRK2 mediated Rab8a phosphorylation promotes lipid storage. | Yu, M., et al. 2018. Lipids Health Dis. 17: 34. PMID: 29482628
- Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes. | Wall, AA., et al. 2019. Philos Trans R Soc Lond B Biol Sci. 374: 20180151. PMID: 30966999
- Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B. | Liu, Y., et al. 2022. Cancer Lett. 535: 215629. PMID: 35278612
- Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/β-Catenin Signaling Pathway. | Cai, S., et al. 2023. Dis Markers. 2023: 8143581. PMID: 36815135
- Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. | Wu, T., et al. 2023. Oncogene. 42: 2801-2815. PMID: 37582861
- Rab8a restores diverse innate functions in CD11c+CD11b+ dendritic cells from aged mice. | Singh, S., et al. 2024. Nat Commun. 15: 10300. PMID: 39604443