Molecular structure of Quinolinic acid, CAS Number: 89-00-9
Quinolinic acid (CAS 89-00-9)
See product citations (7)
Alternate Names:
Pyridine-2,3-dicarboxylic acid
Application:
Quinolinic acid is a matabolite of tryptophan and a putative NMDA receptor agonist
CAS Number:
89-00-9
Purity:
99%
Molecular Weight:
167.1
Molecular Formula:
C7H5NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid (QA) is a naturally occurring compound that is produced during the breakdown of tryptophan through the kynurenine pathway. It serves as a building block for nicotinamide adenine dinucleotide (NAD+) synthesis and plays significant roles in energy metabolism, cell signaling, and immune responses.
Quinolinic acid (CAS 89-00-9) References
- Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse. | Saito, K., et al. 1992. Neuroscience. 51: 25-39. PMID: 1465184
- Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease. | Ryu, JK., et al. 2004. Exp Neurol. 187: 150-9. PMID: 15081596
- Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. | Ryu, JK., et al. 2005. Neurobiol Dis. 20: 550-61. PMID: 15916899
- Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats. | Ribeiro, CA., et al. 2006. J Neurochem. 99: 1531-42. PMID: 17230642
- Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation. | Moresco, RM., et al. 2008. Eur J Nucl Med Mol Imaging. 35: 704-15. PMID: 18080815
- Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans. | Yan, EB., et al. 2015. J Neuroinflammation. 12: 110. PMID: 26025142
- Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid. | Kanchanatawan, B., et al. 2018. Mol Neurobiol. 55: 1524-1536. PMID: 28181189
- The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons. | Peet, MJ., et al. 1987. Neuroscience. 22: 563-71. PMID: 2823176
- Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-α. | Feng, W., et al. 2017. Apoptosis. 22: 696-709. PMID: 28315174
- Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. | Stone, TW. and Perkins, MN. 1981. Eur J Pharmacol. 72: 411-2. PMID: 6268428
- Remote microglial activation in the quinolinic acid model of Huntington's disease. | Töpper, R., et al. 1993. Exp Neurol. 123: 271-83. PMID: 8405289
- Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains. | Achim, CL., et al. 1993. J Clin Invest. 91: 2769-75. PMID: 8514884
- Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. | Heyes, MP., et al. 1996. Biochem J. 320 (Pt 2): 595-7. PMID: 8973572
Inhibitor of:
ACMSD, AFMID, PRODH, and SDHAF2.Activator of:
ALDH8A1, EAAT1, kynureninase, NMDA, PARP S, and QAPRTase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinolinic acid, 1 g | sc-203226 | 1 g | $31.00 |