Date published: 2025-10-19

1-800-457-3801

SCBT Portrait Logo
Seach Input

Pyridoxal-5′-phosphate monohydrate (CAS 41468-25-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Codecarboxylase
Application:
Pyridoxal-5′-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins
CAS Number:
41468-25-1
Purity:
≥97%
Molecular Weight:
265.2
Molecular Formula:
C8H10NO6P•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Pyridoxal-5′-phosphate monohydrate, also known as Pyridoxal phosphate hydrate (PPLH), a vitamin B6 metabolite, exhibits the ability to modify lysyl and valyl residues within proteins. Notably, it possesses inhibitory properties towards purinergic receptors and intracellular calcium influx. Furthermore, this compound can modify peptides and impede their precursor ionization efficiency. Research indicates that cycloserine can inhibit pyridoxal-5′-phosphate-dependent enzymes. Pyridoxal-5′-phosphate monohydrate belongs to the water-soluble derivatives of the vitamin B6 family. As a vital coenzyme, it participates in numerous biochemical reactions involving carbohydrate, protein, and fatty acid metabolism. Additionally, Pyridoxal-5′-phosphate monohydrate plays a role in neurotransmitter synthesis, contributing to normal nerve function. Moreover, it influences gene expression and facilitates DNA repair processes. Pyridoxal-5′-phosphate monohydrate finds extensive use in scientific research, particularly in the fields of biochemistry, molecular biology, and pharmacology. It serves as useful for investigating enzyme mechanisms, assessing enzyme activity, and exploring gene expression regulation. Moreover, Pyridoxal-5′-phosphate monohydrate is involved in neurotransmitter synthesis, playing a critical role in maintaining the proper functioning of the nervous system. Acting as a coenzyme, it binds to enzymes and aids in their activation, facilitating catalytic reactions through electron transfer.


Pyridoxal-5′-phosphate monohydrate (CAS 41468-25-1) References

  1. Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).  |  Kandzari, DE., et al. 2003. Am J Cardiol. 92: 660-4. PMID: 12972102
  2. Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate.  |  Kim, DW., et al. 2005. J Biochem Mol Biol. 38: 58-64. PMID: 15715947
  3. Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study.  |  Tardif, JC., et al. 2007. J Thorac Cardiovasc Surg. 133: 1604-11. PMID: 17532963
  4. Protective effect of pyridoxal-5-phosphate (MC-1) on perioperative myocardial infarction is independent of aortic cross clamp time: results from the MEND-CABG trial.  |  Carrier, M., et al. 2008. J Cardiovasc Surg (Torino). 49: 249-53. PMID: 18431346
  5. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases.  |  Neuwirth, M., et al. 2009. FEBS Lett. 583: 2179-86. PMID: 19523954
  6. Determination of pyridoxal-5'-phosphate (PLP)-bonding sites in proteins: a peptide mass fingerprinting approach based on diagnostic tandem mass spectral features of PLP-modified peptides.  |  Simon, ES. and Allison, J. 2009. Rapid Commun Mass Spectrom. 23: 3401-8. PMID: 19810014
  7. Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.  |  Lowther, J., et al. 2010. Mol Biosyst. 6: 1682-93. PMID: 20445930
  8. Synthesis of oxovanadium(IV) Schiff base complexes derived from C-substituted diamines and pyridoxal-5-phosphate as antitumor agents.  |  Hazari, PP., et al. 2012. Chem Biol Drug Des. 79: 223-34. PMID: 22023804
  9. The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase.  |  Coquille, S., et al. 2012. J Biol Chem. 287: 42333-43. PMID: 23048037
  10. Site-Specific Protein Bioconjugation via a Pyridoxal 5'-Phosphate-Mediated N-Terminal Transamination Reaction.  |  Witus, LS. and Francis, M. 2010. Curr Protoc Chem Biol. 2: 125-34. PMID: 23836553
  11. Pyridoxal-5'-phosphate (MC-1), a vitamin B6 derivative, inhibits expressed P2X receptors.  |  Thériault, O., et al. 2014. Can J Physiol Pharmacol. 92: 189-96. PMID: 24593783
  12. Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations.  |  Ciapaite, J., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165607. PMID: 31759955
  13. High sensitivity and non-background SERS detection of endogenous hydrogen sulfide in living cells using core-shell nanoparticles.  |  Zhang, WS., et al. 2020. Anal Chim Acta. 1094: 106-112. PMID: 31761035

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pyridoxal-5′-phosphate monohydrate, 5 g

sc-202787
5 g
$175.00

Pyridoxal-5′-phosphate monohydrate, 25 g

sc-202787A
25 g
$310.00