PYGB/M Antibody (6F1): sc-51926

PYGB/M Antibody (6F1) is a mouse monoclonal IgG1 antibody that detects the PYGB/M protein of human origin by western blotting (WB) and immunoprecipitation (IP). PYGB/M, or glycogen phosphorylase, plays a crucial role in carbohydrate metabolism by catalyzing the conversion of glycogen into glucose-1-phosphate, a key step in energy production. Anti-PYGB/M antibody (6F1) recognizes an enzyme that is allosterically regulated, meaning its activity can be modulated by the binding of various metabolites, as well as through covalent modifications such as phosphorylation. The importance of glycogen phosphorylase lies in its ability to respond to the energy needs of the cell, making PYGB/M a vital component in maintaining glucose homeostasis. Dysregulation of glycogen phosphorylase can lead to metabolic disorders, including type 2 diabetes mellitus, which has prompted research into inhibitors that target PYGB/M for therapeutic purposes. PYGB/M (6F1) antibody serves as an essential tool for researchers studying the dynamics of glycogen metabolism and its implications in metabolic diseases.

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PYGB/M Antibody (6F1) References:

1. Expression of glycogen phosphorylase isoforms in cultured muscle from patients with McArdle's disease carrying the p.R771PfsX33 PYGM mutation.  |  Nogales-Gadea, G., et al. 2010. PLoS One. 5: PMID: 20957198
2. Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose.  |  Philips, KB., et al. 2014. Cancer Chemother Pharmacol. 73: 349-61. PMID: 24292700
3. Novel variant in the PYGM gene causing late-onset limb-girdle myopathy, ptosis, and camptocormia.  |  Chéraud, C., et al. 2018. Muscle Nerve. 57: 157-160. PMID: 28120463
4. Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.  |  Wang, Z., et al. 2018. Mol Med Rep. 18: 3800-3808. PMID: 30106110
5. Differential proteomic analysis of endometrial fluid suggests increased inflammation and impaired glucose metabolism in non-implantative IVF cycles and pinpoints PYGB as a putative implantation marker.  |  Azkargorta, M., et al. 2018. Hum Reprod. 33: 1898-1906. PMID: 30169642
6. A New Glycogen Storage Disease Caused by a Dominant PYGM Mutation.  |  Echaniz-Laguna, A., et al. 2020. Ann Neurol. 88: 274-282. PMID: 32386344
7. PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer.  |  Xia, B., et al. 2020. Technol Cancer Res Treat. 19: 1533033820926592. PMID: 32462986
8. Whole-exome sequencing detects PYGM variants in two adults with McArdle disease.  |  Thomas-Wilson, A., et al. 2022. Cold Spring Harb Mol Case Stud. 8: PMID: 35022222
9. Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth.  |  Jung, M., et al. 2022. Front Oncol. 12: 841398. PMID: 35402263
10. Development and Validation of a UHPLC-MS/MS Method for the Quantification of a Novel PYGB Inhibitor in Plasma: Application to Pharmacokinetic Studies.  |  Xu, S., et al. 2023. Molecules. 28: PMID: 37836837