PtdIns-(4,5)-P2-biotinamide (sodium salt)
Alternate Names:
Phosphatidylinositol-4,5-diphosphate C-8-biotin
Molecular Weight:
1053.8
Molecular Formula:
C35H61N3O21P3S · 3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
The PtdIns phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(4,5)-P2-biotinamide is an affinity probe which allows PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to function as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
References
1 Rückle, T., Schwarz, M.K., Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 5 903-918 (2006).
Appearance
:
Lyophilized powder
Physical State
:
Solid
Storage
:
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES
:
O[[email protected]] 1[[email protected]] (OP([O-] ) (O) =O) [[email protected]@H] (OP([O-] ) (O) =O) [[email protected]] (O) [[email protected]] (O) [[email protected]@H] 1OP([O-] ) (OC[[email protected]] (COC(CCCCCCCNC(CCCC[[email protected]] 2SC[[email protected]@] (N3[H] ) ([H] ) [[email protected]] 2([H] ) N([H] ) C3=O) =O) =O) OC(CCCCCCC) =O) =O.[Na+] .[Na+] .[Na+]
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