PSR Antibody (APSR-14.4): sc-32740
- PSR Antibody (APSR-14.4) is a Armenian hamster monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against His-tagged PSR of human origin
- recommended for detection of PSR of mouse, rat and human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See PSR (H-7): sc-28348 for PSR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PSR Antibody (APSR-14.4). This work is in progress.
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PSR Antibody (APSR-14.4) is a hamster monoclonal IgG1 antibody that detects phosphatidylserine receptor (PSR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). PSR antibody (APSR-14.4) plays a crucial role in the recognition and clearance of apoptotic cells, as PSR (APSR-14.4) monoclonal antibody specifically binds to phosphatidylserine, which becomes exposed on the outer membrane of cells undergoing apoptosis. This interaction is vital for the phagocytosis of dying cells by immune cells like macrophages and dendritic cells, thereby maintaining tissue homeostasis and preventing inflammation. PSR is predominantly expressed on the surface of macrophages, fibroblasts, and epithelial cells, with particularly high levels found in heart, skeletal muscle, and kidney tissues. Notably, PSR is extensively glycosylated, which is important for its stability and function, as glycosylation can influence protein interactions and signaling pathways. Furthermore, the mammalian phosphatidylserine receptor exhibits significant homology to proteins found in Caenorhabditis elegans and Drosophila melanogaster, indicating that the mechanisms of apoptotic cell clearance have been evolutionarily conserved across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSR Antibody (APSR-14.4) References:
- Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. | De Simone, R., et al. 2004. Mol Neurobiol. 29: 197-212. PMID: 15126686
- The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. | Cikala, M., et al. 2004. BMC Cell Biol. 5: 26. PMID: 15193161
- Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes. | Setty, BN. and Betal, SG. 2008. Blood. 111: 905-14. PMID: 17911385
- The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. | Flannagan, RS., et al. 2014. Mol Biol Cell. 25: 1511-22. PMID: 24623723
- A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. | Yang, H., et al. 2015. Nat Commun. 6: 5717. PMID: 25564762
- Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis. | Yanagihashi, Y., et al. 2017. Proc Natl Acad Sci U S A. 114: 8800-8805. PMID: 28768810
- MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation. | Nishi, C., et al. 2019. J Biol Chem. 294: 7221-7230. PMID: 30846565
- Phosphatidylserine receptor-targeting therapies for the treatment of cancer. | Park, M. and Kang, KW. 2019. Arch Pharm Res. 42: 617-628. PMID: 31172440
- The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry. | Kirui, J., et al. 2021. Cells. 10: PMID: 34359995
- The phosphatidylserine receptor TIM1 promotes infection of enveloped hepatitis E virus. | Corneillie, L., et al. 2023. Cell Mol Life Sci. 80: 326. PMID: 37833515
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSR Antibody (APSR-14.4) | sc-32740 | 200 µg/ml | $316.00 | |||
PSR Antibody (APSR-14.4) FITC | sc-32740 FITC | 200 µg/ml | $330.00 | |||
PSR Antibody (APSR-14.4) PE | sc-32740 PE | 200 µg/ml | $343.00 |