Proteassemblin Antibody (F-3): sc-271491

Proteassemblin Antibody (F-3) is a mouse monoclonal IgG2a antibody that detects Proteassemblin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Proteassemblin, also known as POMP (proteasome maturation protein), UMP1, or Voltage-gated potassium channel β subunit 4.1, is an endoplasmic reticulum (ER)-associated protein that plays a crucial role as a molecular chaperone necessary for the assembly of proteasomes and immunoproteasomes. Proteassemblin is essential for cell viability and is induced by interferon-gamma (IFN-γ), highlighting Proteassemblin′s importance in immune responses and cellular stress management. Proteassemblin specifically interacts with preproteasomes, binding to the 20S β1i, β1, β5, β6, and β7 subunits, thereby facilitating the incorporation of these β subunits into the 20S proteasome. Proteassemblin (F-3) antibody mediates the binding of the 20S preproteasome to the ER membrane, which is critical for proper assembly and function of the proteasome. While Proteassemblin is the human homolog of the yeast Ump1 protein, Proteassemblin differs by degrading upon maturation of the newly formed proteasome, ensuring no persistence in the proteasome complex. anti-Proteassemblin antibody (F-3) serves as an invaluable tool for researchers studying proteasome assembly and function, as well as the broader implications of proteostasis in cellular health and disease.

The preferred Proteassemblin antibody is Proteassemblin Antibody (B-1): sc-393267.