Molecular structure of Proscillaridin A, CAS Number: 466-06-8
Proscillaridin A (CAS 466-06-8)
See product citations (4)
Alternate Names:
Proscillaridin A is also known as Scillarenin 3β-rhamnoside.
Application:
Proscillaridin A is a cardiac glycoside and sodium/potassium ATPase inhibitor first isolated from plants in the genus Scilla.
CAS Number:
466-06-8
Purity:
≥80%
Molecular Weight:
530.66
Molecular Formula:
C30H42O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Proscillaridin A is a cardiac glycoside which functions as a specific Na+/K+-ATPase inhibitor. It is reported that at high concentrations, above 300nM, Proscillaridin A can increase intracellular Ca2+ concentration, activate caspase-3, and induce apoptosis in human fibroblasts. However, in low concentrations Proscillaridin A can activate the proliferation of fibroblasts. Studies suggest that it inhibits both topoisomerase I and II activity simultaneously resulting in cytotoxicity of MCF-7 cells (sc-2206). In addition, Proscillaridin A is more effective at MCF-7 cell proliferation than other cardiac glycosides such as digoxin and ouabain (sc-201548).
Proscillaridin A (CAS 466-06-8) References
- Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells. | Winnicka, K., et al. 2008. Biol Pharm Bull. 31: 1131-40. PMID: 18520043
- Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system. | Winnicka, K., et al. 2010. Acta Pol Pharm. 67: 630-4. PMID: 21229879
- Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells. | He, Y., et al. 2018. Int J Med Sci. 15: 832-839. PMID: 30008594
- Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. | Da Costa, EM., et al. 2019. J Exp Clin Cancer Res. 38: 251. PMID: 31196146
- Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivo. | Fang, S., et al. 2020. Biochem Biophys Res Commun. 521: 880-886. PMID: 31708095
- Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress. | Wang, F., et al. 2020. Cell Cycle. 19: 541-550. PMID: 32009541
- Proscillaridin A inhibits hepatocellular carcinoma progression through inducing mitochondrial damage and autophagy. | Luo, M., et al. 2021. Acta Biochim Biophys Sin (Shanghai). 53: 19-28. PMID: 33201987
- Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells. | Huot, M., et al. 2021. Cancer Chemother Pharmacol. 88: 845-856. PMID: 34331108
- Effect οf elicitοrs οn cell suspensiοn culture οf Urginea maritima L. tοwards prοductiοn οf prοscillaridin A. | Shahin, H., et al. 2022. Front Biosci (Landmark Ed). 27: 45. PMID: 35226988
- Proscillaridin A Sensitizes Human Colon Cancer Cells to TRAIL-Induced Cell Death. | Semba, M., et al. 2022. Int J Mol Sci. 23: PMID: 35805980
- Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells. | Hou, J., et al. 2022. Ann Transl Med. 10: 820. PMID: 36034984
- In vitro stability of proscillaridin A. | Andersson, KE., et al. 1975. Eur J Clin Pharmacol. 8: 135-9. PMID: 9294
- Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. | Schneider, R., et al. 1998. J Biol Chem. 273: 784-92. PMID: 9422732
Inhibitor of:
ATPase, and Enzyme.Activator of:
caspase-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proscillaridin A, 1 mg | sc-500903A | 1 mg | $182.00 | |||
Proscillaridin A, 5 mg | sc-500903B | 5 mg | $494.00 | |||
Proscillaridin A, 10 mg | sc-500903 | 10 mg | $686.00 |