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Propantheline bromide (CAS 50-34-0)

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Alternate Names:
(2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate
Application:
Propantheline bromide is a muscarinic acetylcholine receptor antagonist
CAS Number:
50-34-0
Purity:
≥97%
Molecular Weight:
448.39
Molecular Formula:
C23H30NO3•Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Propantheline bromide is a quaternary ammonium compound that functions as a muscarinic antagonist. It acts by competitively inhibiting the binding of acetylcholine to muscarinic receptors in smooth muscle, secretory glands, and the central nervous system. This results in the blockade of parasympathetic nerve impulses, leading to a reduction in smooth muscle contractions and secretions. Propantheline bromide binds to the M1 and M3 subtypes of muscarinic receptors, thereby preventing the activation of these receptors by acetylcholine. This inhibition ultimately leads to a decrease in the activity of the parasympathetic nervous system, resulting in reduced smooth muscle tone and secretions in various organs and tissues. Propantheline bromide′s mechanism of action involves interfering with the cholinergic signaling pathway, leading to its functional role as a muscarinic antagonist in experimental applications.


Propantheline bromide (CAS 50-34-0) References

  1. A stability-indicating proton nuclear magnetic resonance spectroscopic method for the analysis of propantheline bromide in pharmaceutical samples.  |  Hanna, GM. and Lau-Cam, CA. 2001. Pharmazie. 56: 700-3. PMID: 11593989
  2. Effect of propantheline bromide (pro-banthine) on fluid and electrolyte loss in dogs with pyloric obstruction.  |  ABBOTT, CE., et al. 1957. Can Med Assoc J. 76: 176-80. PMID: 13396670
  3. IR, Raman and SERS spectra of propantheline bromide.  |  Baraldi, C., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 103: 1-10. PMID: 23228825
  4. Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode.  |  Abd El-Rahman, MK., et al. 2015. Talanta. 132: 52-8. PMID: 25476278
  5. [Propantheline bromide is effective against dog drooling].  |  Gyldenløve, M. and Thyssen, JP. 2015. Ugeskr Laeger. 177: V67934. PMID: 26692220
  6. Transforming Growth Factor Beta (TGFβ1) and Epidermal Growth Factor (EGF) as Biomarkers of Leishmania (V) braziliensis Infection and Early Therapeutic Response in Cutaneous Leishmaniasis: Studies in Hamsters.  |  Montoya, A., et al. 2018. Front Cell Infect Microbiol. 8: 350. PMID: 30333964
  7. A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells.  |  Littmann, T., et al. 2018. Sci Rep. 8: 17179. PMID: 30464299
  8. A versatile, automated and high-throughput drug screening platform for zebrafish embryos.  |  Lubin, A., et al. 2021. Biol Open. 10: PMID: 34472582
  9. Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies.  |  Unadkat, V., et al. 2022. Onco Targets Ther. 15: 479-495. PMID: 35535170
  10. Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs.  |  Qin, Q., et al. 2022. J Enzyme Inhib Med Chem. 37: 2241-2255. PMID: 35978496
  11. Discovery and structural optimization of 3-O-β-Chacotriosyl betulonic acid saponins as potent fusion inhibitors of Omicron virus infections.  |  Liu, M., et al. 2023. Bioorg Chem. 131: 106316. PMID: 36508939
  12. Kinetics and mechanism of the solid-state decomposition of propantheline bromide.  |  Yoshioka, S. and Uchiyama, M. 1986. J Pharm Sci. 75: 92-6. PMID: 3958915
  13. Effects of propantheline bromide and milk plus cheese on healing of chronic gastric ulcers in rats.  |  Okabe, S. and Pfeiffer, CJ. 1973. Am J Dig Dis. 18: 746-50. PMID: 4725318
  14. Reproductive toxicology. Propantheline bromide.  |  . 1997. Environ Health Perspect. 105 Suppl 1: 339-40. PMID: 9114352

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Propantheline bromide, 5 g

sc-253320
5 g
$47.00