PRL-1 Antibody (269): sc-130354
- PRL-1 Antibody (269) is a mouse monoclonal IgG1 PRL-1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant PRL-1 of mouse origin
- recommended for detection of PRL-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; non cross-reactive with PRL-2 or PRL-3
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRL-1 Antibody (269). This work is in progress.
PRL-1 Antibody (269) is a mouse monoclonal IgG1 antibody that detects PRL-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRL-1 antibody (269) is available as the non-conjugated format. PRL-1, also known as Protein Tyrosine Phosphatase Type IVA Protein 1 (PTP4A1), plays a crucial role in cellular signaling and regulation, particularly in cell growth and differentiation. PRL-1 is primarily localized in the nucleus, suggesting involvement in regulating gene expression and cellular responses to external stimuli. PRL-1 is notably induced in regenerating liver and mitogen-stimulated cells, highlighting importance in tissue repair and immune responses. PRL-1 is overexpressed in various tumor cell lines, indicating potential involvement in oncogenic processes. A C-terminal prenylation consensus sequence characterizes PRL-1′s structure, allowing proper localization and function within cells, making PRL-1 a critical target for understanding cancer biology and developing therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRL-1 Antibody (269) References:
- Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome. | Zeng, Q., et al. 2000. J Biol Chem. 275: 21444-52. PMID: 10747914
- Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. | Matter, WF., et al. 2001. Biochem Biophys Res Commun. 283: 1061-8. PMID: 11355880
- PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. | Zeng, Q., et al. 2003. Cancer Res. 63: 2716-22. PMID: 12782572
- Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. | Jeong, DG., et al. 2005. J Mol Biol. 345: 401-13. PMID: 15571731
- Studies on nickel metabolism: interaction with other mineral elements. | Ling, JR. and Leach, RM. 1979. Poult Sci. 58: 591-6. PMID: 514946
- Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. | Zeng, Q., et al. 1998. Biochem Biophys Res Commun. 244: 421-7. PMID: 9514946
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRL-1 Antibody (269) | sc-130354 | 200 µg/ml | $316.00 |