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Porphobilinogen (CAS 487-90-1)

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Alternate Names:
5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
Application:
Porphobilinogen is an intermediate in the biosynthesis of heme
CAS Number:
487-90-1
Purity:
≥96%
Molecular Weight:
226.23
Molecular Formula:
C10H14N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Porphobilinogen is a key intermediate in the biosynthesis of heme, chlorophyll, and other tetrapyrroles, which are essential compounds for various biological functions. In biochemical research, it is pivotal in studies aimed at elucidating the enzymatic steps involved in the formation of these macrocycles. Researchers utilize porphobilinogen to investigate the activity of enzymes such as porphobilinogen deaminase and to understand the genetic and enzymatic basis of disorders like acute intermittent porphyria. Moreover, studies involving porphobilinogen are fundamental in plant and microbial research, where the compound′s role in chlorophyll and heme production is connected to photosynthesis and respiration. In the field of biotechnology, porphobilinogen is used to engineer bacteria and plants with enhanced biosynthetic pathways for the production of commercially valuable tetrapyrroles.


Porphobilinogen (CAS 487-90-1) References

  1. Quantitative measurement of porphobilinogen in urine by stable-isotope dilution liquid chromatography-tandem mass spectrometry.  |  Ford, RE., et al. 2001. Clin Chem. 47: 1627-32. PMID: 11514396
  2. Simultaneous determination of delta-aminolevulinic acid, porphobilinogen, levulinic acid and glycine in culture broth by capillary electrophoresis.  |  Kim, JN., et al. 2001. J Chromatogr A. 938: 137-43. PMID: 11771832
  3. Porphobilinogen as a porphyrin precursor, and interconversion of porphyrins, in a tissue system.  |  FALK, JE., et al. 1953. Nature. 172: 292-4. PMID: 13087195
  4. Quantitative determination of porphobilinogen and delta-aminolevulinic acid in the urine.  |  MALOOLY, DA. and HIGHTOWER, NC. 1962. J Lab Clin Med. 59: 568-74. PMID: 14469034
  5. Estimation and application of biological variation of urinary delta-aminolevulinic acid and porphobilinogen in healthy individuals and in patients with acute intermittent porphyria.  |  Aarsand, AK., et al. 2006. Clin Chem. 52: 650-6. PMID: 16595824
  6. Facile synthesis of a 'ready to use' precursor of porphobilinogen and its amino Acid derivatives.  |  Soldermann, CP., et al. 2008. J Org Chem. 73: 764-7. PMID: 18081349
  7. Evaluation of a commercially available rapid urinary porphobilinogen test.  |  Vogeser, M. and Stauch, T. 2011. Clin Chem Lab Med. 49: 1491-4. PMID: 21627493
  8. A LC-MS/MS method for the specific, sensitive, and simultaneous quantification of 5-aminolevulinic acid and porphobilinogen.  |  Zhang, J., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 2389-96. PMID: 21783436
  9. Travelling wave ion mobility mass spectrometry of 5-aminolaevulinic acid, porphobilinogen and porphyrins.  |  Benton, CM., et al. 2012. Rapid Commun Mass Spectrom. 26: 480-6. PMID: 22279024
  10. Direct and simultaneous quantitation of 5-aminolaevulinic acid and porphobilinogen in human serum or plasma by hydrophilic interaction liquid chromatography-atmospheric pressure chemical ionization/tandem mass spectrometry.  |  Benton, CM., et al. 2013. Biomed Chromatogr. 27: 267-72. PMID: 23180457
  11. Effect of porphobilinogen on the formation of garlic green pigments.  |  Mou, C., et al. 2013. J Sci Food Agric. 93: 2454-7. PMID: 23436238
  12. Screening tests for porphobilinogen are insensitive. The problem and its solution.  |  Schreiber, WE., et al. 1989. Am J Clin Pathol. 92: 644-9. PMID: 2816816
  13. Presynaptic neuromuscular inhibition by porphobilinogen and porphobilin.  |  Feldman, DS., et al. 1971. Proc Natl Acad Sci U S A. 68: 383-6. PMID: 4322608
  14. Failure of delta-aminolaevulinic acid and porphobilinogen to alter renal salt and water excretion in the dog.  |  Unikowsky, B. and Levy, M. 1983. Can J Physiol Pharmacol. 61: 363-8. PMID: 6860998
  15. Induction of porphobilinogen oxygenase and porphobilinogen deaminase in rat blood under conditions of erythropoietic stress.  |  Tomaro, ML., et al. 1981. Biochim Biophys Acta. 676: 31-42. PMID: 7260110

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Porphobilinogen, 1 mg

sc-215735
1 mg
$114.00

Porphobilinogen, 5 mg

sc-215735A
5 mg
$364.00