POMGnT1 Antibody (JD.23): sc-130459

POMGnT1 Antibody (JD.23) is a mouse monoclonal IgG2a kappa light chain antibody that detects POMGnT1 protein of mouse, rat, and human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). POMGnT1 (JD.23) antibody is available as a non-conjugated format. The POMGNT1 gene encodes protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, which plays a crucial role in O-mannosyl glycan synthesis, essential for proper cellular function and signaling. POMGnT1 protein is primarily localized in the medial-Golgi apparatus, where POMGnT1 initiates the conversion of high-mannose N-glycans to complex N-glycans, a process vital for glycoprotein structural integrity and functionality. POMGnT1 serves as a glycosylation enzyme synthesizing O-mannosyl glycans, critical for laminin binding to alpha-dystroglycan, a protein significant in muscle and brain development. POMGNT1 gene mutations can lead to severe conditions such as muscle-eye-brain disease (MEB), characterized by congenital muscular dystrophy, ocular defects, and lissencephaly, highlighting proper glycosylation′s importance in maintaining cellular health. The human POMGNT1 gene, located on chromosome 1p34-p33, encodes a 660-amino acid type II transmembrane protein, underscoring POMGnT1′s complex structure and functional significance in cellular processes.

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POMGnT1 Antibody (JD.23) References:

1. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1.  |  Yoshida, A., et al. 2001. Dev Cell. 1: 717-24. PMID: 11709191
2. Deficiency of alpha-dystroglycan in muscle-eye-brain disease.  |  Kano, H., et al. 2002. Biochem Biophys Res Commun. 291: 1283-6. PMID: 11883957
3. Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies.  |  Michele, DE., et al. 2002. Nature. 418: 417-22. PMID: 12140558
4. Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome.  |  Beltrán-Valero de Bernabé, D., et al. 2002. Am J Hum Genet. 71: 1033-43. PMID: 12369018
5. The transmembrane and flanking sequences of beta 1,2-N-acetylglucosaminyltransferase I specify medial-Golgi localization.  |  Burke, J., et al. 1992. J Biol Chem. 267: 24433-40. PMID: 1447191

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-POMGnT1 Antibody (JD.23) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-POMGnT1 Antibody (JD.23) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

POMGnT1 Antibody (JD.23) Specifications

Alternate Product Name: POMGnT1

Product Clone Name: JD.23

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 221-319

Epitope Target: POMGnT1

Epitope Species: human

Product Reactivity/Detection: POMGnT1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for POMGnT1 Antibody (JD.23): N/A