PMM2 Antibody (AT3B4): sc-517420

PMM2 Antibody (AT3B4) is a mouse monoclonal IgG2a antibody that detects PMM2 in human samples through applications such as western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). PMM2, or phosphomannomutase 2, is a crucial enzyme consisting of 246 amino acids that plays a vital role in the synthesis of GDP-mannose, a key precursor for glycoprotein biosynthesis. The proper functioning of PMM2 is essential because defects in this enzyme can lead to carbohydrate-deficient glycoprotein syndrome type I, an autosomal recessive disorder that results in severe neurological impairments, including encephalopathy, psychomotor retardation, and peripheral neuropathy, as well as other systemic manifestations such as abnormal fat distribution and hypogonadism. The gene encoding PMM2 is located on human chromosome 16p13.2, and understanding its structure and function is critical for developing therapeutic strategies for conditions arising from its mutations. Anti-PMM2 antibody (AT3B4) provides a reliable tool for researchers investigating the role of this important protein in health and disease.

The preferred PMM2 antibody is PMM2 Antibody (2A5): sc-517179.