Molecular structure of (±)α-Methylserotonin maleate, CAS Number: 304-52-9
(±)α-Methylserotonin maleate (CAS 304-52-9)
Application:
(±)α-Methylserotonin maleate is a SR-2A, SR-2B, and SR-2C agonist
CAS Number:
304-52-9
Molecular Weight:
306.3
Molecular Formula:
C11H14N2O•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
(±)α-Methylserotonin maleate is a racemic mixture of α-Methylserotonin maleate and is a serotonin (SR) receptor agonist with preference for SR-2A, SR-2B, and SR-2C. (±)α-Methylserotonin maleate has been utilized in studies of aggression involving the central amygdaloid nucleus in female Wistar rats. Additional studies with frog spinal cord motoneurons in the presence of NMDA receptor open-channel blockers and high concentrations of α-methy-5-hydroxytryptamine indicated that these high concentrations significantly potentiated NMDA-induced depolarizations in these motoneurons.
(±)α-Methylserotonin maleate (CAS 304-52-9) References
- Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. | Holohean, AM. and Hackman, JC. 2004. Br J Pharmacol. 143: 351-60. PMID: 15339859
- The effect of 5-HT(2a/2c) receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats. | de Almeida, RM., et al. 2006. Braz J Psychiatry. 28: 130-4. PMID: 16810397
- 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. | Wilson, H., et al. 1990. J Pharmacol Exp Ther. 252: 683-8. PMID: 1968974
- 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin. | Ismaiel, AM., et al. 1990. J Med Chem. 33: 755-8. PMID: 2299641
Inhibitor of:
Olfr818.Activator of:
SR-2B, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)α-Methylserotonin maleate, 10 mg | sc-201134 | 10 mg | $67.00 | |||
(±)α-Methylserotonin maleate, 50 mg | sc-201134A | 50 mg | $291.00 |