(+)-Epibatidine dihydrochloride (CAS 166374-43-2)
QUICK LINKS
A non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, which suggest that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles.
(+)-Epibatidine dihydrochloride (CAS 166374-43-2) References
- Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. | Gerzanich, V., et al. 1995. Mol Pharmacol. 48: 774-82. PMID: 7476906
- The influence of Bay K 8644 treatment on (+/-)-epibatidine-induced analgesia. | Bannon, AW., et al. 1995. Brain Res. 678: 244-50. PMID: 7542542
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Epibatidine dihydrochloride, 5 mg | sc-252777 | 5 mg | $810.00 |