PKD2 Antibody (H-6): sc-374213
- PKD2 Antibody (H-6) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 847-876 at the C-terminus of PKD2 of human origin
- recommended for detection of PKD2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for PKD2 Antibody (H-6) for WB applications. This reagent is now offered in a bundle with PKD2 Antibody (H-6) (see ordering information below).
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PKD2 Antibody (H-6) is a mouse monoclonal IgG3 antibody that detects PKD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PKD2, also known as protein kinase D2 or PRKD2, plays a crucial role in various cellular processes, including proliferation, apoptosis, and signal transduction, by acting as a calcium-independent, phospholipid-dependent protein kinase. PKD2 is primarily located in both the cytoplasm and nucleus, where PKD2 shuttles between these compartments to exert functions. Nuclear translocation of PKD2 facilitates transcriptional activation of key genes such as Nur77 while simultaneously excluding histone deacetylase 7 (HDAC7) from the nucleus. This dynamic localization underscores PKD2′s significance in regulating gene expression in response to extracellular signals, particularly those mediated by G-protein-coupled receptors. Anti-PKD2 antibody (H-6) serves as an essential tool for researchers exploring PKD2′s intricate roles in cellular signaling pathways and implications in various physiological and pathological contexts.
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PKD2 Antibody (H-6) References:
- Novel roles of Pkd2 in male reproductive system development. | Nie, X. and Arend, LJ. 2014. Differentiation. 87: 161-71. PMID: 24951251
- Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. | Bulley, S., et al. 2018. Elife. 7: PMID: 30511640
- Truncating PKHD1 and PKD2 mutations alter energy metabolism. | Chumley, P., et al. 2019. Am J Physiol Renal Physiol. 316: F414-F425. PMID: 30566001
- High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition. | Pang, Z., et al. 2019. Sci Rep. 9: 1324. PMID: 30718593
- circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma. | Gao, L., et al. 2019. Mol Carcinog. 58: 1783-1794. PMID: 31206208
- Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure. | MacKay, CE., et al. 2020. Elife. 9: PMID: 32364494
- Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. | Gao, L., et al. 2022. Cell Death Dis. 13: 192. PMID: 35220397
- Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. | Obata, Y., et al. 2023. Cell Rep. 42: 113035. PMID: 37616163
- Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma. | Liu, Y., et al. 2024. Chem Biol Interact. 387: 110794. PMID: 37951334
- The Small Interactor of PKD2 protein promotes the assembly and ciliary entry of the Chlamydomonas PKD2-mastigoneme complexes. | Das, P., et al. 2024. J Cell Sci. 137: PMID: 38063216
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKD2 Antibody (H-6) | sc-374213 | 200 µg/ml | $322.00 | |||
PKD2 Antibody (H-6): m-IgG3 BP-HRP Bundle | sc-550449 | 200 µg Ab; 40 µg BP | $361.00 | |||
PKD2 (H-6) Neutralizing Peptide | sc-374213 P | 100 µg/0.5 ml | $69.00 |