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PKC ε inhibitor peptide

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Alternate Names:
PKCε Translocation Inhibitor Peptide; EAVSLKPT; Protein Kinase Cε Translocation Inhibitor Peptide
Application:
PKC ε inhibitor peptide is selectively and reversibly inhibits the translocation of Protein Kinase C epsilon
Purity:
≥97%
Molecular Weight:
844
Molecular Formula:
C37H65N9O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The PKC ε inhibitor peptide represents a crucial tool in contemporary molecular research, providing insights into the complex regulatory mechanisms controlled by protein kinase C epsilon (PKC ε) isoform within cellular signaling networks. This peptide inhibitor, meticulously designed to target PKC ε, effectively disrupts its enzymatic activity and subsequent downstream signaling pathways. By specifically inhibiting the interaction between PKC ε and its substrates, this peptide enables researchers to delineate the functional roles of PKC ε in various cellular processes, including cell proliferation, differentiation, and apoptosis. Through its mechanism of action, the PKC ε inhibitor peptide facilitates precise manipulation of PKC ε activity, offering a means to dissect its involvement in intracellular signaling cascades and cellular responses to external stimuli. Widely utilized in biochemical and cell biology studies, this inhibitor has contributed significantly to advancing our understanding of PKC-mediated signaling and its implications in diverse physiological and pathological conditions. Ongoing research employing this inhibitor continues to unravel novel regulatory mechanisms governing PKC ε function and its interplay with other signaling molecules, underscoring its significance as a valuable tool for deciphering the complexities of cellular signaling networks.


PKC ε inhibitor peptide References

  1. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.  |  Johnson, JA., et al. 1996. J Biol Chem. 271: 24962-6. PMID: 8798776
  2. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.  |  Yedovitzky, M., et al. 1997. J Biol Chem. 272: 1417-20. PMID: 8999804

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PKC ε inhibitor peptide, 1 mg

sc-3095
1 mg
$45.00

Hello, I am interested in using this PKC epsilon inhibitor in RAW 264.7 cells. Would you recommend transfecting the cells with the inhibitor/scrambled peptide, or is simple incubation with the inhibitor sufficient? Many thanks Sonia

Asked by: Son123
Thank you for your question. Since the peptide is not cell permeable, we recommend transient permeabilization with saponin at 150 µg/ml. You can find more information about the use of this peptide in these references: Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417. Johnson, J.A., et al. 1996. J. Biol. Chem. 271, 24962. https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&orig_db=pubmed&term=EAVSLKPT If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-07-05
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Rated 5 out of 5 by from Worked wellWorked well, no complaints.
Date published: 2015-07-16
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PKC ε inhibitor peptide is rated 5.0 out of 5 by 1.
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