PIPK II α Antibody (149.1): sc-100406

PIPK II α Antibody (149.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PIPK II alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PIPK II alpha antibody (149.1) is available as the non-conjugated format. PIPK II alpha protein plays a crucial role in synthesizing phosphatidylinositol-4,5-bisphosphate, a lipid vital for various cellular processes, including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. PIPK II alpha protein is predominantly located in the brain, contributing to the regulation of signaling pathways essential for neuronal function and communication. PIPK family is classified into three types, with type II PIPKs, including PIPK II α and β, being particularly important for their high expression levels in neural tissues. PIPK II alpha presence in the brain underscores significance in neurobiology, involving modulation of synaptic activity and plasticity, fundamental for learning and memory. Through facilitating phosphatidylinositol-4,5-bisphosphate production, PIPK II alpha serves as a key messenger in signal transduction pathways, making PIPK II alpha an important target for research in neurodegenerative diseases and other conditions affecting the nervous system.

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PIPK II α Antibody (149.1) References:

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5. Enzymes phosphorylating lipids and polysaccharides.  |  Karataeva, NA. and Nevinsky, GA. 2007. Biochemistry (Mosc). 72: 367-79. PMID: 17511601
6. The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P(2).  |  Kanaho, Y., et al. 2007. Biol Pharm Bull. 30: 1605-9. PMID: 17827707
7. Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells.  |  Weixel, KM., et al. 2007. J Biol Chem. 282: 36534-42. PMID: 17940289
8. Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.  |  Sinha, RK. and Subrahmanyam, G. 2007. Indian J Biochem Biophys. 44: 289-94. PMID: 18341203
9. Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.  |  Nelson, CD., et al. 2008. J Biol Chem. 283: 21093-101. PMID: 18534983
10. PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis.  |  Hu, A., et al. 2018. J Lipid Res. 59: 507-514. PMID: 29353240
11. PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells.  |  Roy, A., et al. 2023. Autophagy. 19: 2464-2484. PMID: 36803256
12. Exploring the Potential Role of Oligodendrocyte-Associated PIP4K2A in Alzheimer's Disease Complicated with Type 2 Diabetes Mellitus via Multi-Omic Analysis.  |  Nguyen, DPQ., et al. 2024. Int J Mol Sci. 25: PMID: 38928345

The preferred PIPK II antibody is PIPK II Antibody (D-3): sc-393246.