Molecular structure of Pipendoxifene, CAS Number: 198480-55-6
Pipendoxifene (CAS 198480-55-6)
Alternate Names:
2-(4-hydroxyphenyl)-3-methyl-1-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]-1H-indol-5-ol; ERA 923
CAS Number:
198480-55-6
Molecular Weight:
456.58
Molecular Formula:
C29H32N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pipendoxifene is a nonsteroidal 2-phenyl indole and a selective estrogen receptor modulator (SERM) with potential antineoplastic activity. It antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer. In addition, this agent also exerts intrinsic estrogenic activity depending on the tissue types.
Pipendoxifene (CAS 198480-55-6) References
- The future of the new selective estrogen receptor modulators. | Palacios, S. 2007. Menopause Int. 13: 27-34. PMID: 17448265
- Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer. | Peng, J., et al. 2009. Anticancer Agents Med Chem. 9: 481-99. PMID: 19519291
- 2-Arylindoles: a privileged molecular scaffold with potent, broad-ranging pharmacological activity. | Lal, S. and Snape, TJ. 2012. Curr Med Chem. 19: 4828-37. PMID: 22830349
- Tissue selective estrogen complexes (TSECs) differentially modulate markers of proliferation and differentiation in endometrial cells. | Kulak, J., et al. 2013. Reprod Sci. 20: 129-37. PMID: 23171676
- The role of sevista in the management of dysfunctional uterine bleeding. | Bs, D. and Nanda, SK. 2013. J Clin Diagn Res. 7: 132-4. PMID: 23450207
- Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer. | Wardell, SE., et al. 2015. Clin Cancer Res. 21: 5121-5130. PMID: 25991817
- Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles. | Kelly, PM., et al. 2016. Bioorg Med Chem. 24: 4075-4099. PMID: 27407030
- Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system. | Segura-Uribe, JJ., et al. 2017. Neural Regen Res. 12: 1231-1240. PMID: 28966632
- Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer. | Kaur, K. and Jaitak, V. 2019. Anticancer Agents Med Chem. 19: 962-983. PMID: 30864529
- Endocrine and Targeted Therapy for Hormone-Receptor-Positive, HER2-Negative Advanced Breast Cancer: Insights to Sequencing Treatment and Overcoming Resistance Based on Clinical Trials. | El Sayed, R., et al. 2019. Front Oncol. 9: 510. PMID: 31281796
- Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches. | Ciallella, HL., et al. 2021. Lab Invest. 101: 490-502. PMID: 32778734
- Next-Generation Endocrine Therapies for Breast Cancer. | McDonnell, DP., et al. 2021. J Clin Oncol. 39: 1383-1388. PMID: 33705209
- Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer. | Jana, AK., et al. 2021. J Med Chem. 64: 16293-16316. PMID: 34726897
- Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. | Hosfield, DJ., et al. 2022. Elife. 11: PMID: 35575456
- Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity. | Bender, O., et al. 2023. ACS Omega. 8: 6968-6981. PMID: 36844536
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pipendoxifene, 10 mg | sc-476266 | 10 mg | $364.00 | |||
Pipendoxifene, 100 mg | sc-476266A | 100 mg | $3027.00 |