Molecular structure of Physostigmine-d3, CAS Number: 57-47-6 (unlabeled)
Physostigmine-d3 (CAS 1217704-11-4)
Alternate Names:
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate Ester-d3
Application:
Physostigmine-d3 is a useful deuterium-labeled analogue of Physostigmine
CAS Number:
1217704-11-4
Molecular Weight:
278.36
Molecular Formula:
C15H18D3N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Physostigmine-d3 is a deuterium-labeled analogue of Physostigmine (sc-202764). Physostigmine is an alkaloid originally derived from the Calabar bean (Physostigma venenosum) and noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). This compound has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier in a research study.
Physostigmine-d3 (CAS 1217704-11-4) References
- Effects of subcutaneous and intracerebroventricular injection of physostigmine on the acute corneal nociception in rats. | Tamaddonfard, E. and Hamzeh-Gooshchi, N. 2010. Pharmacol Rep. 62: 858-63. PMID: 21098868
- Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. | Kalogiannis, M., et al. 2011. PLoS One. 6: e18697. PMID: 21533254
- Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds. | Valli, M., et al. 2011. Curr Med Chem. 18: 3423-30. PMID: 21728957
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Physostigmine-d3, 1 mg | sc-219617 | 1 mg | $310.00 |