Date published: 2025-10-15

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Phosphoglycolic Acid (CAS 13147-57-4)

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Alternate Names:
2-(Phosphonooxy)acetic Acid; (Phosphonooxy)acetic Acid; Glycolic Acid Phosphate; Glycolic Acid, di-H Phosphate; Glycolic Acid, Dihydrogen Phosphate; 2-Phosphoglycolic Acid; Glycophosphoric Acid
CAS Number:
13147-57-4
Molecular Weight:
156.03
Molecular Formula:
C2H5O6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phosphoglycolic Acid (2-PGA) is a key metabolite within the glycolytic pathway. This compound holds great importance as an intermediate during the metabolism of photosynthetic organisms and plays a role in the process of photorespiration. Additionally, Phosphoglycolic Acid has been utilized as a marker to assess oxidative stress in plants, and it holds potential as a biomarker. Beyond its integral function in plant metabolism, Phosphoglycolic Acid has displayed remarkable potential for various applications in scientific research, owing to its distinctive chemical properties. The mechanism of action of 2-Phosphoglycolic Acid revolves around its interaction with enzymes associated with the glycolytic pathway. Acting as a substrate, it engages these enzymes, facilitating the conversion of 2-Phosphoglycolic Acid into various metabolites, including phosphoenolpyruvate and pyruvate. This catalytic process sheds light on the intricate functioning of these enzymes and their role in metabolic pathways.


Phosphoglycolic Acid (CAS 13147-57-4) References

  1. A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase.  |  Shalom-Barak, T. and Knaus, UG. 2002. J Biol Chem. 277: 40659-65. PMID: 12189148
  2. New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases.  |  Fonvielle, M., et al. 2004. Bioorg Med Chem Lett. 14: 2923-6. PMID: 15125960
  3. Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli.  |  Schryvers, A., et al. 1978. J Biol Chem. 253: 783-8. PMID: 340460
  4. Potential mechanisms of the anti-hypertensive effects of RVPSL on spontaneously hypertensive rats using non-targeted serum metabolomics.  |  Yu, Z., et al. 2021. Food Funct. 12: 8561-8569. PMID: 34337639
  5. Analysis of serum metabolism in premature infants before and after feeding using GC-MS and the relationship with necrotizing enterocolitis.  |  Wang, F., et al. 2023. Biomed Chromatogr. 37: e5505. PMID: 36093571
  6. Differential metabolites in cirrhotic patients with hepatitis B and muscle mass loss.  |  Liu, X., et al. 2023. Front Nutr. 10: 1068779. PMID: 36875836
  7. Purification and characterization of glycerol-3-phosphate dehydrogenase (flavin-linked) from rat liver mitochondria.  |  Garrib, A. and McMurray, WC. 1986. J Biol Chem. 261: 8042-8. PMID: 3711123
  8. Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1.  |  Winters, TA., et al. 1994. Nucleic Acids Res. 22: 1866-73. PMID: 7516064
  9. NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase.  |  Harris, TK., et al. 1997. Biochemistry. 36: 14661-75. PMID: 9398185

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phosphoglycolic Acid, 10 mg

sc-477531
10 mg
$475.00