Date published: 2025-9-5

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Phenylbenzene ω-phosphono-α-amino acid

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Alternate Names:
3-[2′-Phosphonomethyl[1,1′-biphenyl]-3-yl]alanine; PMBA
Application:
Phenylbenzene ω-phosphono-α-amino acid is a selective strychnine-sensitive GlyR antagonist
Molecular Weight:
335.29
Molecular Formula:
C16H18NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phenylbenzene ω-phosphono-α-amino acid is a compound that functions as a competitive inhibitor of certain enzymes involved in cellular processes. It acts by binding to the active site of the enzyme, preventing the substrate from binding and inhibiting the enzyme′s activity. Phenylbenzene Ω-Phosphono-Å-Amino Acid targets enzymes involved in the biosynthesis of important cellular components, disrupting the normal metabolic pathways. By interfering with these enzymatic reactions, it can be used to study the specific roles of these enzymes in cellular function and metabolism. Its mechanism of action allows for the investigation of potential targets and the development of new strategies for modulating cellular processes.


Phenylbenzene ω-phosphono-α-amino acid References

  1. Depolarizing glycine responses in Cajal-Retzius cells of neonatal rat cerebral cortex.  |  Kilb, W., et al. 2002. Neuroscience. 112: 299-307. PMID: 12044448
  2. Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord.  |  Bradaïa, A. and Trouslard, J. 2002. J Physiol. 544: 727-39. PMID: 12411519
  3. Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity.  |  Shay, BL., et al. 2005. J Neurophysiol. 94: 2867-77. PMID: 16033939
  4. Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons.  |  Adermark, L., et al. 2011. Neurochem Int. 58: 693-9. PMID: 21333709
  5. Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.  |  Mordel, J., et al. 2011. J Physiol. 589: 2287-300. PMID: 21486797
  6. Subregion-Specific Modulation of Excitatory Input and Dopaminergic Output in the Striatum by Tonically Activated Glycine and GABA(A) Receptors.  |  Adermark, L., et al. 2011. Front Syst Neurosci. 5: 85. PMID: 22028683
  7. Interactions between superficial and deep dorsal horn spinal cord neurons in the processing of nociceptive information.  |  Petitjean, H., et al. 2012. Eur J Neurosci. 36: 3500-8. PMID: 22967006
  8. Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain.  |  Medrano, MC., et al. 2016. Pain. 157: 1432-1442. PMID: 26934510
  9. Glycine receptor regulation of neurokinin1 receptor function in rat dorsal horn neurones.  |  Heppenstall, PA. and Fleetwood-Walker, SM. 1997. Neuroreport. 8: 3109-12. PMID: 9331923

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phenylbenzene ω-phosphono-α-amino acid, 10 mg

sc-301540
10 mg
$286.00