Phenobarbital Antibody (F1#4A11B62): sc-57972

Phenobarbital Antibody (F1#4A11B62) is a mouse monoclonal IgG1 antibody that detects Phenobarbital in non-species reactive samples by enzyme-linked immunosorbent assay (ELISA). Phenobarbital is a barbiturate that serves as one of the most widely used anticonvulsants globally, particularly recognized for treating neonatal seizures. Phenobarbital′s mechanism of action involves enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) at the GABA-A receptor, which is crucial for maintaining neuronal excitability and preventing seizures. This function is particularly important in neonatal care, where effective seizure management is vital for preventing long-term neurological damage. Phenobarbital′s ability to modulate GABAergic transmission underscores clinical significance, despite side effects including dizziness, nystagmus, and ataxia. Phenobarbital undergoes hepatic metabolism primarily through hydroxylation and glucuronidation, with renal excretion, highlighting the importance of liver and kidney function in pharmacokinetics. With a molecular weight of 232.235 g/mol and a half-life ranging from 53 to 118 hours, Phenobarbital′s pharmacological profile makes this agent critical in managing seizure disorders.