PGRP-Iβ Antibody (186C426): sc-52945

PGRP-Iβ Antibody (186C426) is a mouse monoclonal IgG1 antibody that detects PGRP-I beta protein of mouse, rat, human, and porcine origin by western blotting (WB). Anti-PGRP-I beta antibody (186C426) is available as a non-conjugated format. PGRP-I beta protein plays a crucial role in immune response by recognizing peptidoglycan, a key component of bacterial cell walls, which is essential for identification and elimination of bacterial pathogens. In mammals, PGRP-I beta functions as an antibacterial protein, contributing to innate immune system by binding to peptidoglycan and facilitating activation of immune pathways. PGRP-I beta, along with PGRP-Iα, is expressed in various tissues, including esophagus, tonsils, and thymus, where both help maintain mucosal immunity. PGRP-I beta is a transmembrane protein composed of 373 amino acids, featuring at least three highly conserved C-terminal PGRP domains that are critical for pathogen recognition. PGRP-I beta′s ability to bind specifically to Gram-positive bacteria underscores importance in host defense mechanism, making PGRP-I beta a valuable target for research in immunology and infectious diseases.

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PGRP-Iβ Antibody (186C426) References:

1. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.  |  Liu, C., et al. 2001. J Biol Chem. 276: 34686-94. PMID: 11461926
2. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.  |  Wang, ZM., et al. 2003. J Biol Chem. 278: 49044-52. PMID: 14506276
3. Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha.  |  Guan, R., et al. 2004. J Biol Chem. 279: 31873-82. PMID: 15140887
4. [Overview: Innate immunity and peptideglycan recognition protein].  |  Natori, S. 2004. Tanpakushitsu Kakusan Koso. 49: 1156-60. PMID: 15209209
5. Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.  |  Uehara, A., et al. 2005. Cell Microbiol. 7: 675-86. PMID: 15839897
6. Recognition of Staphylococcus aureus by the innate immune system.  |  Fournier, B. and Philpott, DJ. 2005. Clin Microbiol Rev. 18: 521-40. PMID: 16020688
7. Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S.  |  Kumar, S., et al. 2005. J Biol Chem. 280: 37005-12. PMID: 16129677
8. Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.  |  Wang, H., et al. 2005. Infect Immun. 73: 7216-25. PMID: 16239516
9. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria.  |  Guan, R., et al. 2006. Protein Sci. 15: 1199-206. PMID: 16641493

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGRP-Iβ Antibody (186C426) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PGRP-Iβ Antibody (186C426) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGRP-Iβ Antibody (186C426) Specifications

Alternate Product Name: PGRP-Iβ

Product Clone Name: 186C426

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 95-110

Epitope Target: PGRP-Iβ

Epitope Species: human

Product Reactivity/Detection: PGRP-Iβ

Species Reactivity/Detection: mouse, rat, human, porcine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PGRP-Iβ Antibody (186C426): N/A