Perlecan Antibody (CSI 001-76): sc-59644
- Perlecan Antibody (CSI 001-76) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against lysed corneal endothelial cells and extracellular matrix of bovine origin
- recommended for detection of Perlecan of human and bovine origin by WB, IP and IF; may cross-react with human thrombospondin; non cross-reactive with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin)
- See Perlecan (E-6): sc-377219 for Perlecan antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Perlecan Antibody (CSI 001-76). This work is in progress.
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Perlecan Antibody (CSI 001-76) is a mouse monoclonal IgG1 antibody that detects Perlecan in human and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Perlecan is a vital heparan sulfate proteoglycan that plays a crucial role in the extracellular matrix, influencing various cellular processes including growth, differentiation, and adhesion. Anti-Perlecan antibody (CSI 001-76) recognizes five distinct domains that facilitate interactions with a wide array of matrix molecules, cytokines, and growth factors, which are essential for cartilage development and the proper functioning of neuromuscular junctions. Perlecan′s ability to modulate growth factor activities is particularly important in tumor biology, as Perlecan can influence tumor cell metastasis and angiogenesis. Perlecan expression is regulated by key proteins such as antithrombin, which inhibits expression, and TGFβ1, which stimulates expression, highlighting the intricate balance of signaling pathways that can be targeted for therapeutic interventions in cancer. With multifaceted roles in cellular dynamics and disease processes, Perlecan remains a significant focus for research and potential clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Perlecan Antibody (CSI 001-76) References:
- Perlecan and tumor angiogenesis. | Jiang, X. and Couchman, JR. 2003. J Histochem Cytochem. 51: 1393-410. PMID: 14566013
- Schwartz-Jampel syndrome and perlecan deficiency. | Stum, M., et al. 2005. Acta Myol. 24: 89-92. PMID: 16550923
- Perlecan (basement membrane heparan sulfate proteoglycan) and its role in oral malignancies: an overview. | Mishra, M., et al. 2011. Indian J Dent Res. 22: 823-6. PMID: 22484878
- A current view of perlecan in physiology and pathology: A mosaic of functions. | Gubbiotti, MA., et al. 2017. Matrix Biol. 57-58: 285-298. PMID: 27613501
- Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia. | Trout, AL., et al. 2020. Int J Mol Sci. 21: PMID: 31968632
- Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment. | Cruz, LA., et al. 2020. Adv Exp Med Biol. 1245: 133-146. PMID: 32266656
- Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues. | Guilak, F., et al. 2021. Int J Mol Sci. 22: PMID: 33800241
- Impact of perlecan, a core component of basement membrane, on regeneration of cartilaginous tissues. | Gao, G., et al. 2021. Acta Biomater. 135: 13-26. PMID: 34454085
- Perlecan Improves Blood Spinal Cord Barrier Repair Through the Integrin β1/ROCK/MLC Pathway After Spinal Cord Injury. | Xie, C., et al. 2023. Mol Neurobiol. 60: 51-67. PMID: 36216996
- Perlecan: the multidomain heparan sulphate proteoglycan of basement membrane and extracellular matrix. | Murdoch, AD. and Iozzo, RV. 1993. Virchows Arch A Pathol Anat Histopathol. 423: 237-42. PMID: 8236820
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perlecan Antibody (CSI 001-76) | sc-59644 | 100 µg/ml | $339.00 |