Date published: 2025-12-5

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Perfluoroheptanoic acid (CAS 375-85-9)

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Alternate Names:
Perfluoroheptanoic acid; Tridecafluoroheptanoic acid
Application:
Perfluoroheptanoic acid is a fluorinated fatty acid for proteomics and metabolomics research
CAS Number:
375-85-9
Molecular Weight:
364.06
Molecular Formula:
C7HF13O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Perfluoroheptanoic acid (PFHpA) is a synthetic carboxylic acid that has been widely adopted in diverse scientific and industrial applications due to its fluorinated nature. This highly stable compound is characterized by its non-volatility, non-flammability, non-corrosiveness, and resistance to various solvents and chemicals. In the realm of scientific research, perfluoroheptanoic acid finds multiple applications. It serves as a valuable substrate in enzyme assays, facilitating the examination of enzyme activity, particularly in relation to proteases and lipases. Furthermore, it proves instrumental in investigations pertaining to fatty acid metabolism and serves as a model compound for the study of metabolic processes involving other substances. Additionally, perfluoroheptanoic acid is utilized in toxicity studies concerning fluorinated compounds and contributes to our understanding of the environmental fate of perfluorinated compounds. Due to its lipophilic nature, perfluoroheptanoic acid exhibits the ability to traverse cellular membranes and engage with proteins and enzymes within the cell. By binding to these proteins and enzymes, it influences their activity and function.


Perfluoroheptanoic acid (CAS 375-85-9) References

  1. Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK.  |  Kim, M., et al. 2015. Int J Mol Med. 36: 1693-700. PMID: 26459765
  2. Sorption of perfluorooctanoic acid, perfluorooctane sulfonate and perfluoroheptanoic acid on granular activated carbon.  |  Zhang, D., et al. 2016. Chemosphere. 144: 2336-42. PMID: 26606188
  3. Determination of selected synthetic cannabinoids and their metabolites by micellar electrokinetic chromatography--mass spectrometry employing perfluoroheptanoic acid-based micellar phase.  |  Švidrnoch, M., et al. 2016. Talanta. 150: 568-76. PMID: 26838444
  4. Exposure of Juncus effusus to seven perfluoroalkyl acids: Uptake, accumulation and phytotoxicity.  |  Zhang, W., et al. 2019. Chemosphere. 233: 300-308. PMID: 31176131
  5. Remediation of perfluorooctanoic acid (PFOA) polluted soil using pulsed corona discharge plasma.  |  Zhan, J., et al. 2020. J Hazard Mater. 387: 121688. PMID: 31776082
  6. Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats.  |  Han, JS., et al. 2020. Arch Toxicol. 94: 523-539. PMID: 31797001
  7. Perfluoroheptanoic acid induces Leydig cell hyperplasia but inhibits spermatogenesis in rats after pubertal exposure.  |  Li, Z., et al. 2021. Toxicology. 448: 152633. PMID: 33220336
  8. Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.  |  Yu, G., et al. 2021. Environ Int. 156: 106621. PMID: 33984575
  9. Assessment of exposure to perfluoroalkyl substances (PFASs) in dogs by fur analysis.  |  Makowska, K., et al. 2021. Environ Pollut. 286: 117435. PMID: 34052650
  10. Perfluoroalkyl Substances in the Western Tropical Atlantic Ocean.  |  Miranda, DA., et al. 2021. Environ Sci Technol. 55: 13749-13758. PMID: 34617730
  11. Implication of cation-bridging interaction contribution to sorption of perfluoroalkyl carboxylic acids by soils.  |  Wang, W., et al. 2022. Chemosphere. 290: 133224. PMID: 34896418
  12. Swimming with PFAS in public and private pools.  |  Martinez, B., et al. 2023. Chemosphere. 310: 136765. PMID: 36241119
  13. Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model.  |  Weatherly, LM., et al. 2023. Food Chem Toxicol. 171: 113515. PMID: 36435305
  14. Developmental and mitochondrial toxicity assessment of perfluoroheptanoic acid (PFHpA) in zebrafish (Danio rerio).  |  Huang, M., et al. 2023. Environ Toxicol Pharmacol. 97: 104037. PMID: 36526081
  15. Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice.  |  Zhou, Y., et al. 2023. Ecotoxicol Environ Saf. 260: 115072. PMID: 37262965

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Perfluoroheptanoic acid, 5 g

sc-236337
5 g
$66.00