PEDF Antibody (H-9): sc-390066
- PEDF Antibody (H-9) is a mouse monoclonal IgG1 (lambda light chain) provided at 200 µg/ml
- raised against amino acids 281-405 of PEDF of human origin
- recommended for detection of PEDF of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PEDF Antibody (H-9) for WB applications. These reagents are now offered in bundles with PEDF Antibody (H-9) (see ordering information below).
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PEDF Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects pigment epithelium-derived growth factor (PEDF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PEDF is a crucial glycoprotein predominantly secreted by retinal pigment epithelium cells, playing a significant role in neuroprotection and neuronal differentiation. PEDF is part of the serine protease inhibitor (Serpin) superfamily and inhibits angiogenesis and the proliferation of various cell types, making PEDF vital in maintaining ocular health and preventing pathological conditions such as diabetic retinopathy. The strategic localization of PEDF within the interphotoreceptor matrix allows PEDF to effectively influence the underlying neural retina, thereby enhancing neuroprotective effects. PEDF has been shown to promote the survival of central nervous system neurons, protecting them from degeneration induced by serum withdrawal or glutamate toxicity, which underscores PEDF′s importance in neurobiology and potential therapeutic applications.
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PEDF Antibody (H-9) References:
- The applied biochemistry of PEDF and implications for tissue homeostasis. | Broadhead, ML., et al. 2010. Growth Factors. 28: 280-5. PMID: 20166889
- Anti-atherothrombogenic properties of PEDF. | Yamagishi, SI. and Matsui, T. 2010. Curr Mol Med. 10: 284-91. PMID: 20236055
- PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. | He, X., et al. 2015. Clin Sci (Lond). 128: 805-23. PMID: 25881671
- The Role of RAD6B and PEDF in Retinal Degeneration. | Ye, Q., et al. 2022. Neuroscience. 480: 19-31. PMID: 34774969
- The Role of PEDF in Reproductive Aging of the Ovary. | Nemerovsky, L., et al. 2022. Int J Mol Sci. 23: PMID: 36142276
- Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration. | Bernardo-Colón, A., et al. 2023. J Lipid Res. 64: 100358. PMID: 36934843
- Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF. | Fan, R., et al. 2023. J Nanobiotechnology. 21: 327. PMID: 37684667
- PEDF Prevents Mitochondrial Function Decay and ER Stress Induced by Rotenone in Aging RPE Cells. | Zhang, R., et al. 2023. Front Biosci (Landmark Ed). 28: 319. PMID: 38062839
- A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function. | Chen, S., et al. 2024. Ocul Surf. 32: 1-12. PMID: 38103731
- PEDF peptide plus hyaluronic acid stimulates cartilage regeneration in osteoarthritis via STAT3-mediated chondrogenesis. | Lu, YC., et al. 2024. Bone Joint Res. 13: 137-148. PMID: 38555936
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PEDF Antibody (H-9) | sc-390066 | 200 µg/ml | $322.00 | |||
PEDF Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-540749 | 200 µg Ab; 10 µg BP | $361.00 | |||
PEDF Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-542346 | 200 µg Ab; 20 µg BP | $361.00 |