PECI Antibody (32): sc-136374

PECI Antibody (32) is a mouse monoclonal IgG1 kappa light chain antibody that detects PECI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PECI antibody (32) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). PECI protein, also known as peroxisomal D3,D2-enoyl-CoA isomerase, DRS1, ACBD2, or HCA88, is a crucial 359 amino acid protein localized in the peroxisomal matrix, where PECI plays a vital role in lipid metabolism. PECI is essential for the isomerization of 3-cis and 3-trans double bonds into the 2-trans form across a variety of enoyl-CoA species, which is particularly important for the beta-oxidation of unsaturated fatty acids. This process is critical for energy production and the maintenance of cellular lipid homeostasis. The gene encoding PECI is located on human chromosome 6, a region that is significant not only for its size—comprising nearly 6% of the human genome—but also for its association with various health conditions, including early onset intestinal cancer and other genetic disorders. The presence of PECI and PECI′s interactions with other proteins involved in fatty acid metabolism underscore PECI′s importance in both normal physiology and disease states, making PECI monoclonal antibody (32) a valuable tool for researchers studying metabolic pathways and related disorders.

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PECI Antibody (32) References:

1. Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor.  |  Suk, K., et al. 1999. Biochim Biophys Acta. 1454: 126-31. PMID: 10354522
2. Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes.  |  Geisbrecht, BV., et al. 1999. J Biol Chem. 274: 21797-803. PMID: 10419495
3. Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse.  |  Janssen, U. and Stoffel, W. 2002. J Biol Chem. 277: 19579-84. PMID: 11916962
4. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
5. Peroxisomal Delta(3),Delta(2)-enoyl CoA isomerases and evolution of cytosolic paralogues in embryophytes.  |  Goepfert, S., et al. 2008. Plant J. 56: 728-42. PMID: 18657232
6. Parental Post-Traumatic Stress Symptoms as Predictors of Psychosocial Problems in Children Treated for Cancer.  |  Nakajima-Yamaguchi, R., et al. 2016. Int J Environ Res Public Health. 13: PMID: 27529259
7. Systematic review of clinical practice guidelines for uveitis.  |  Ghadiri, N., et al. 2023. BMJ Open Ophthalmol. 8: PMID: 37278434
8. Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox.  |  Middelkamp, S., et al. 2023. Cell Genom. 3: 100389. PMID: 37719152
9. Ligand Modification-Free Methods for the Profiling of Protein-Environmental Chemical Interactions.  |  Li, Y., et al. 2024. Chem Res Toxicol. 37: 1-15. PMID: 38146056
10. Peroxisomal beta-oxidation and polyunsaturated fatty acids.  |  Hiltunen, JK., et al. 1996. Ann N Y Acad Sci. 804: 116-28. PMID: 8993540

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PECI Antibody (32) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PECI Antibody (32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PECI Antibody (32) Specifications

Alternate Product Name: PECI

Product Clone Name: 32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-103

Epitope Target: PECI isoform 2

Epitope Species: human

Product Reactivity/Detection: PECI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PECI Antibody (32): AC: Agarose, HRP: Horseradish Peroxidase