PCDHGA5 Antibody (12C1): sc-134417
- PCDHGA5 Antibody (12C1) is a mouse monoclonal IgG2a κ PCDHGA5 antibody provided at 100 µg/ml
- raised against recombinant PCDHGA5 protein of human origin
- recommended for detection of PCDHGA5 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PCDHGA5 Antibody (12C1). This work is in progress.
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PCDHGA5 Antibody (12C1) is a mouse monoclonal IgG2a kappa light chain antibody that detects PCDHGA5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHGA5 antibody (12C1) is available as a non-conjugated monoclonal isotype antibody. Protocadherins, including PCDHGA5, play a crucial role in establishing and maintaining neuronal connections in the brain, which is vital for proper neural function and communication. PCDHGA5 monoclonal antibody (12C1) recognizes a member of the protocadherin gamma cluster, which consists of three subfamilies (A, B, and C) and is essential for neuronal survival due to its localization at synapses. PCDHGA5, comprising 931 amino acids, features six cadherin motifs and functions as a type I transmembrane receptor predominantly expressed in the central nervous system. PCDHGA5 undergoes alternative splicing, resulting in two isoforms that may have distinct functional roles in neuronal connectivity and signaling. PCDHGA5′s ability to interact with other proteins in the gamma cluster further underscores its importance in synaptic stability and neuronal health, making PCDHGA5 (12C1) antibody a valuable tool for researchers studying neural development and disorders.
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PCDHGA5 Antibody (12C1) References:
- A striking organization of a large family of human neural cadherin-like cell adhesion genes. | Wu, Q. and Maniatis, T. 1999. Cell. 97: 779-90. PMID: 10380929
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. | Wu, Q., et al. 2001. Genome Res. 11: 389-404. PMID: 11230163
- Gamma protocadherins are required for survival of spinal interneurons. | Wang, X., et al. 2002. Neuron. 36: 843-54. PMID: 12467588
- Variation in the protocadherin gamma A gene cluster. | Kirov, G., et al. 2003. Genomics. 82: 433-40. PMID: 13679023
- Differential expression of individual gamma-protocadherins during mouse brain development. | Frank, M., et al. 2005. Mol Cell Neurosci. 29: 603-16. PMID: 15964765
- Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion. | Reiss, K., et al. 2006. J Biol Chem. 281: 21735-21744. PMID: 16751190
- Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing. | Bonn, S., et al. 2007. Mol Cell Biol. 27: 4121-32. PMID: 17403907
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCDHGA5 Antibody (12C1) | sc-134417 | 100 µg/ml | $333.00 |