PCDH7 Antibody (2D7): sc-517042
- PCDH7 Antibody (2D7) is a mouse monoclonal IgG2a κ PCDH7 antibody, cited in 2 publications, provided at 100 µg/ml
- raised against amino acids 31-124 representing partial length PCDH7 of human origin
- recommended for detection of PCDH7 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PCDH7 Antibody (2D7). This work is in progress.
PCDH7 Antibody (2D7) is a mouse monoclonal IgG2a kappa light chain antibody that detects PCDH7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDH7 antibody (2D7) is available as a non-conjugated format. Protocadherin 7 (PCDH7), also known as BHPCDH or BH-Pcdh, is a 1069 amino acid single-pass membrane protein predominantly expressed in brain and heart, where PCDH7 plays a crucial role in cell-cell recognition and adhesion. PCDH7 contains seven cadherin domains, which are essential for function in mediating cell adhesion, a process vital for maintaining structural integrity of tissues and facilitating communication between cells. PCDH7 exists as three isoforms due to alternative splicing, which may contribute to diverse functional roles in different cellular contexts. The unique adhesion mechanism of protocadherins, including PCDH7, distinguishes them from classic cadherins, and alterations in PCDH7 expression have been implicated in various cancers, highlighting potential as targets for therapeutic intervention.
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PCDH7 Antibody (2D7) References:
- cDNA cloning and chromosomal mapping of mouse BH-protocadherin. | Yoshida, K., et al. 1999. DNA Seq. 10: 43-7. PMID: 10565544
- BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain. | Yoshida, K., et al. 1999. FEBS Lett. 460: 93-8. PMID: 10571067
- Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. | Zhang, Z. and DuBois, RN. 2001. Oncogene. 20: 4450-6. PMID: 11494140
- Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7a and 7b isoforms of protocadherin 7, but not the 7c isoform. | Yoshida, K. 2003. Cell Mol Biol Lett. 8: 735-41. PMID: 12949613
- Spatiotemporal expression pattern of non-clustered protocadherin family members in the developing rat brain. | Kim, SY., et al. 2007. Neuroscience. 147: 996-1021. PMID: 17614211
- Protocadherin family: diversity, structure, and function. | Morishita, H. and Yagi, T. 2007. Curr Opin Cell Biol. 19: 584-92. PMID: 17936607
- Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. | Singh, AP., et al. 2008. Cancer Lett. 259: 28-38. PMID: 17977648
- Genome-wide analysis of survival in early-stage non-small-cell lung cancer. | Huang, YT., et al. 2009. J Clin Oncol. 27: 2660-7. PMID: 19414679
- Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily. | Yoshida, K., et al. 1998. Genomics. 49: 458-61. PMID: 9615233
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCDH7 Antibody (2D7) | sc-517042 | 100 µg/ml | $322.00 |