PC-PLD2 Antibody (1C5): sc-293214
- PC-PLD2 Antibody (1C5) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against a partial recombinant protein mapping within amino acids 834-933 of PC-PLD2 of human origin
- recommended for detection of PC-PLD2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PC-PLD2 Antibody (1C5). This work is in progress.
PC-PLD2 Antibody (1C5) is a mouse monoclonal IgG2a antibody that detects phosphatidylcholine phospholipase D2 (PC-PLD2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PC-PLD2 plays a crucial role in cellular processes by localizing to the plasma membrane, where PC-PLD2 is involved in the formation of endocytotic vesicles, a key step in cellular uptake and signaling. This localization is significant because PC-PLD2 interacts with various membrane receptors and participates in the regulation of macrophage phagocytosis, thereby influencing immune responses. Additionally, PC-PLD2 is activated by G protein-coupled and receptor tyrosine kinase cell surface receptors, which leads to the stimulation of downstream signaling pathways, including the phosphorylation of ERK and the secretion of interleukin-8 in bronchial epithelial cells. PC-PLD2 enhances protein kinase C zeta activity through direct interaction, independent of lipase activity, further underscoring PC-PLD2′s importance in cellular signaling and growth regulation. By repressing the expression of the p21 gene through both p53-dependent and p53-independent pathways, PC-PLD2 may also contribute to processes that lead to carcinogenesis, making PC-PLD2 a protein of interest in cancer research. Anti-PC-PLD2 antibody (1C5) is an essential tool for researchers studying these critical biological functions and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PC-PLD2 Antibody (1C5) References:
- Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. | Lee, YH. and Bae, YS. 2014. FEBS Lett. 588: 3251-8. PMID: 25064843
- Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity. | Park, MH., et al. 2015. Exp Mol Med. 47: e196. PMID: 26611735
- Accumulating insights into the role of phospholipase D2 in human diseases. | Ghim, J., et al. 2016. Adv Biol Regul. 61: 42-6. PMID: 26695710
- Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. | Fu, P., et al. 2020. J Biol Chem. 295: 7669-7685. PMID: 32327488
- Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase. | Kim, MK., et al. 2021. BMB Rep. 54: 112-117. PMID: 32843133
- Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1. | Lee, H., et al. 2021. Exp Mol Med. 53: 1287-1297. PMID: 34471223
- Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma. | Perez-Valle, A., et al. 2022. Oncol Lett. 23: 140. PMID: 35340556
- Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability. | Kim, HJ., et al. 2022. Exp Mol Med. 54: 1146-1155. PMID: 35945449
- Phospholipase D2 targeted by miR-5132-5p alleviates cerulein-induced acute pancreatitis via the Nrf2/NFκB pathway. | Wu, H., et al. 2023. Immun Inflamm Dis. 11: e831. PMID: 37249288
- Phospholipase D2 drives cellular lipotoxicity and tissue inflammation in alcohol-associated liver disease. | Guo, Y., et al. 2024. Life Sci. 358: 123166. PMID: 39447730
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PC-PLD2 Antibody (1C5) | sc-293214 | 100 µg/ml | $316.00 |