Date published: 2026-6-29

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PC-766B (CAS 108375-77-5)

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Alternate Names:
5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Application:
PC-766B is an antibiotic with activity against gram positive bacteria and some fungi and yeasts
CAS Number:
108375-77-5
Molecular Weight:
776.99
Molecular Formula:
C43H68O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PC-766B, a chemical primarily explored in the field of biochemical research, demonstrates interesting activity as an inhibitor of bacterial quorum sensing. Quorum sensing is a process by which bacteria communicate through the production and detection of small signaling molecules, coordinating their behavior in response to population density. PC-766B has been utilized in various studies to explore the disruption of these signaling pathways, thereby providing insights into bacterial communication and its impact on microbial ecology. The mechanism of action of PC-766B involves the inhibition of the synthesis or function of autoinducer molecules, which are pivotal in the quorum sensing process. By disrupting these signaling pathways, PC-766B aids in the study of how bacteria regulate gene expression in response to changes in their microenvironment, affecting phenomena such as biofilm formation and virulence factor production. Research utilizing PC-766B has significantly contributed to understanding the molecular strategies bacteria use to sense and adapt to their surroundings


PC-766B (CAS 108375-77-5) References

  1. Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification.  |  McCauley, M., et al. 2024. J Med Chem. 67: 4483-4495. PMID: 38452116
  2. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation.  |  Kumagai, K., et al. 1993. J Antibiot (Tokyo). 46: 1139-44. PMID: 8360110
  3. Elevation of low density lipoprotein-receptor mRNA concentration in human hepatoma HepG2 cells by macrolide antibiotics.  |  Ogasawara, M., et al. 1993. J Antibiot (Tokyo). 46: 866-8. PMID: 8390431
  4. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. I. Taxonomy, fermentation and biological activity.  |  Kumagai, K., et al. 1993. J Antibiot (Tokyo). 46: 972-8. PMID: 8393851
  5. PC-766B'and PC-766B, 16-Membered Maerolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56.  |  Ko and Hack-Ryong, et al. 2002. Journal of microbiology and biotechnology. 12.5: 829-833.
  6. Synthesis of C18–C28 ketone fragment of micromonospolide B possessing 1, 3-diene and 1, 3-anti-diol functionalities.  |  Sun, et al. 2009. Tetrahedron: Asymmetry. 20.16: 1864-1870.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PC-766B, 1 mg

sc-397304
1 mg
$235.00