Pbx 3b Antibody (9.5): sc-101855

Pbx 3b Antibody (9.5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 3b protein of mouse, rat, and human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 3b antibody (9.5) is available as the non-conjugated format. Pbx 3b protein plays a crucial role in regulating gene expression during development and differentiation, functioning as a transcription factor that interacts with other proteins to modulate target gene activity. This interaction is vital for proper cellular processes, including hematopoiesis and organogenesis, as Pbx 3b helps establish and maintain various cell type identities. Pbx proteins, including Pbx 3b, belong to the TALE (three amino acid loop extension) family, characterized by their homeodomain structure that enables DNA binding and transcription regulation. Pbx 3b′s importance in developmental biology is highlighted by ubiquitous expression in both fetal and adult tissues, along with involvement in certain leukemias associated with chromosomal rearrangements. Understanding Pbx 3b function and interactions can provide insights into gene regulation mechanisms and potential disease implications, making anti-Pbx 3b antibody (9.5) a valuable research tool for studying these processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Pbx 3b Antibody (9.5) References:

1. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.  |  Toresson, H., et al. 2000. Mech Dev. 94: 183-7. PMID: 10842069
2. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.  |  Wagner, K., et al. 2001. Mech Dev. 103: 127-31. PMID: 11335119
3. Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities.  |  Milech, N., et al. 2001. Genes Chromosomes Cancer. 32: 275-80. PMID: 11579467
4. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.  |  Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
5. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.  |  Nourse, J., et al. 1990. Cell. 60: 535-45. PMID: 1967982
6. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.  |  Kamps, MP., et al. 1990. Cell. 60: 547-55. PMID: 1967983
7. PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells.  |  Han, H., et al. 2015. Nat Commun. 6: 8271. PMID: 26420065
8. MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3.  |  Li, B., et al. 2017. Biochem Biophys Res Commun. 484: 241-247. PMID: 28111340
9. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner.  |  Han, Y., et al. 2021. Mol Cell Biochem. 476: 1387-1400. PMID: 33389498
10. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.  |  Lu, Q., et al. 1994. Mol Cell Biol. 14: 3938-48. PMID: 7910944
11. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.  |  Monica, K., et al. 1994. Mol Cell Biol. 14: 8304-14. PMID: 7969166
12. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  |  LeBrun, DP. and Cleary, ML. 1994. Oncogene. 9: 1641-7. PMID: 8183558

The preferred Pbx 1/2/3/4 antibody is Pbx 1/2/3/4 Antibody (F-3): sc-28313.