Pbx 2 Antibody (H-7): sc-377164
- Pbx 2 Antibody (H-7) is a mouse monoclonal IgA κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 12-41 at the N-terminus of Pbx 2 of human origin
- recommended for detection of Pbx 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-377164 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pbx 2 Antibody (H-7). This work is in progress.
Pbx 2 Antibody (H-7) is a mouse monoclonal IgA antibody that detects Pbx 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pbx 2, a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, plays a crucial role in regulating gene expression during development and differentiation. Anti-Pbx 2 antibody (H-7) forms heterodimers with other proteins, such as E2A, which are essential for the proper functioning of transcriptional networks that govern cellular processes. Pbx 2 is ubiquitously expressed in various tissues, including lymphoid cells, highlighting its importance in both normal physiological functions and potential pathological conditions, such as leukemias. Expression of Pbx 2 in these cells suggests involvement in critical signaling pathways that influence cell fate decisions and responses to external stimuli. With versatile applications and significant biological relevance, anti-Pbx 2 antibody (H-7) serves as an invaluable tool for researchers investigating the roles of Pbx proteins in health and disease.
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Pbx 2 Antibody (H-7) References:
- A complex containing PBX2 contributes to activation of the proto-oncogene HOX11. | Brake, RL., et al. 2002. Biochem Biophys Res Commun. 294: 23-34. PMID: 12054735
- Retinoic acid regulates the expression of PBX1, PBX2, and PBX3 in P19 cells both transcriptionally and post-translationally. | Qin, P., et al. 2004. J Cell Biochem. 92: 147-63. PMID: 15095411
- Prep1/Pbx2 complexes regulate CCL2 expression through the -2578 guanine polymorphism. | Wright, EK., et al. 2008. Genes Immun. 9: 419-30. PMID: 18480829
- The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway. | Errico, MC., et al. 2013. Int J Cancer. 133: 879-92. PMID: 23400877
- Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects. | Zhao, Y., et al. 2016. Int Forum Allergy Rhinol. 6: 537-43. PMID: 26852910
- STAT6, PBX2, and PBRM1 Emerge as Predicted Regulators of 452 Differentially Expressed Genes Associated With Puberty in Brahman Heifers. | Nguyen, LT., et al. 2018. Front Genet. 9: 87. PMID: 29616079
- Association of genomic variants at PAX8 and PBX2 with cervical cancer risk. | Ramachandran, D., et al. 2021. Int J Cancer.. PMID: 33905146
- The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins. | Neuteboom, ST., et al. 1995. Proc Natl Acad Sci U S A. 92: 9166-70. PMID: 7568094
- Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2. | van Dijk, MA., et al. 1995. Mech Dev. 52: 99-108. PMID: 7577680
- The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. | Aguado, B. and Campbell, RD. 1995. Genomics. 25: 650-9. PMID: 7759099
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pbx 2 Antibody (H-7) | sc-377164 | 200 µg/ml | $322.00 | |||
Pbx 2 (H-7) Neutralizing Peptide | sc-377164 P | 100 µg/0.5 ml | $69.00 | |||
Pbx 2 Antibody (H-7) X | sc-377164 X | 200 µg/0.1 ml | $322.00 |