Molecular structure of Pazufloxacin, CAS Number: 127045-41-4
Pazufloxacin (CAS 127045-41-4)
CAS Number:
127045-41-4
Molecular Weight:
318.30
Molecular Formula:
C16H15FN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pazufloxacin is an antibacterial agent that functions by inhibiting the bacterial DNA gyrase enzyme. This inhibition prevents the relaxation of supercoiled DNA, leading to the accumulation of double-stranded breaks in the bacterial DNA. As a result, the replication and transcription processes in the bacteria are disrupted, ultimately leading to bacterial cell death. Pazufloxacin targets the A subunit of DNA gyrase, interfering with its ability to catalyze the negative supercoiling of DNA. This mechanism of action makes Pazufloxacin effective against a broad spectrum of Gram-negative and Gram-positive bacteria. By disrupting the DNA processes in bacteria, Pazufloxacin plays a role in inhibiting bacterial growth and proliferation within experimental applications.
Pazufloxacin (CAS 127045-41-4) References
- In vitro activities of pazufloxacin, a novel injectable quinolone, against bacteria causing infections in obstetric and gynecological patients. | Mikamo, H., et al. 1999. Chemotherapy. 45: 154-7. PMID: 10224336
- Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats. | Shimizu, A., et al. 2004. Eur J Pharmacol. 501: 151-9. PMID: 15464074
- In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species. | Higa, F., et al. 2005. J Antimicrob Chemother. 56: 1053-7. PMID: 16260445
- Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats. | Lou, S., et al. 2007. Eur J Drug Metab Pharmacokinet. 32: 219-23. PMID: 18348471
- Spectroscopic studies on the interaction of pazufloxacin with calf thymus DNA. | Ling, X., et al. 2008. J Photochem Photobiol B. 93: 172-6. PMID: 18945625
- Simultaneous measurement of pazufloxacin, ciprofloxacin, and levofloxacin in human serum by high-performance liquid chromatography with fluorescence detection. | Watabe, S., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 1555-61. PMID: 20439169
- Generalized fixed drug eruption caused by pazufloxacin. | Sawada, Y., et al. 2011. Acta Derm Venereol. 91: 600-1. PMID: 21597677
- Photochemical properties and phototoxicity of Pazufloxacin: a stable and transient study. | Liu, Y., et al. 2013. J Photochem Photobiol B. 118: 58-65. PMID: 23218540
- First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma. | Sousa, J., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 930: 104-11. PMID: 23727874
- Effects of repeated oral administration of pazufloxacin mesylate and meloxicam on the antioxidant status in rabbits. | Khan, AM. and Rampal, S. 2014. J Am Assoc Lab Anim Sci. 53: 399-403. PMID: 25199097
- Mutant prevention concentrations of levofloxacin, pazufloxacin and ciprofloxacin for A. baumannii and mutations in gyrA and parC genes. | Sun, C., et al. 2015. J Antibiot (Tokyo). 68: 313-7. PMID: 25351948
- Clinical pharmacokinetics and pharmacodynamic target attainment of pazufloxacin in prostate tissue: Dosing considerations for prostatitis. | Nakamura, K., et al. 2017. J Infect Chemother. 23: 809-813. PMID: 28923301
- Effect of levofloxacin, pazufloxacin, enrofloxacin, and meloxicam on the immunolocalization of ABCG-2 transporter protein in rabbit retina. | Khan, AM., et al. 2018. Environ Sci Pollut Res Int. 25: 8853-8860. PMID: 29330817
- Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. The Pazufloxacin STD Group. | Tanaka, M., et al. 1998. Antimicrob Agents Chemother. 42: 579-82. PMID: 9517935
- Therapeutic effects of an injectable new quinolone, pazufloxacin, against polymicrobial infections in the uterine endometritis model. | Mikamo, H., et al. 1998. Chemotherapy. 44: 99-102. PMID: 9551239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pazufloxacin, 25 mg | sc-228898 | 25 mg | $131.00 |