PANK1/2 Antibody (C-4): sc-390595

PANK1/2 Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects PANK1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PANK1/2 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The PANK (pantothenate kinase) proteins are crucial for the physiological regulation of intracellular coenzyme A (CoA) concentrations, which are vital for numerous metabolic pathways, including fatty acid synthesis and energy production. PANK1 and PANK2, consisting of 598 and 570 amino acids respectively, exist as four alternatively spliced isoforms, with PANK2 being ubiquitously expressed while isoform 1 of PANK1 is predominantly found in the brain, heart, kidney, liver, skeletal muscle, and testis, and isoform 2 is expressed in kidney, liver, brain, and testis. The genes encoding PANK1 and PANK2 are located on human chromosomes 10q23.3 and 20p13, respectively. Notably, defects in PANK2 are linked to several serious conditions, including hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP), as well as neurodegeneration with brain iron accumulation type 1 (NBIA1), an autosomal recessive disorder characterized by iron accumulation in the basal ganglia, which can lead to significant neurological impairment.

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PANK1/2 Antibody (C-4) References:

1. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.  |  Zhou, B., et al. 2001. Nat Genet. 28: 345-9. PMID: 11479594
2. An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria.  |  Hörtnagel, K., et al. 2003. Hum Mol Genet. 12: 321-7. PMID: 12554685
3. PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.  |  Ramaswamy, G., et al. 2004. J Lipid Res. 45: 17-31. PMID: 14523052
4. Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsions.  |  Nicholas, AP., et al. 2005. Mov Disord. 20: 880-6. PMID: 15834858
5. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.  |  Hong, BS., et al. 2007. J Biol Chem. 282: 27984-93. PMID: 17631502
6. p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins.  |  Böhlig, L., et al. 2011. Nucleic Acids Res. 39: 440-53. PMID: 20833636
7. Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.  |  Leonardi, R., et al. 2014. Diabetologia. 57: 1466-75. PMID: 24781151
8. Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload.  |  Audam, TN., et al. 2021. Am J Physiol Heart Circ Physiol. 321: H784-H797. PMID: 34533403
9. Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.  |  Zi, Y., et al. 2022. Int J Biol Sci. 18: 1539-1554. PMID: 35280671
10. circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease.  |  Liu, Q., et al. 2022. Cell Death Dis. 13: 477. PMID: 35589691
11. PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database.  |  Wang, B., et al. 2022. Transl Cancer Res. 11: 2321-2337. PMID: 35966310
12. Coenzyme A biosynthesis: mechanisms of regulation, function and disease.  |  Barritt, SA., et al. 2024. Nat Metab. 6: 1008-1023. PMID: 38871981

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PANK1/2 Antibody (C-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PANK1/2 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PANK1/2 Antibody (C-4) Specifications

Alternate Product Name: PANK1/2

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 401-596

Epitope Target: PANK1

Epitope Species: human

Product Reactivity/Detection: PANK1 and PANK2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PANK1/2 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PANK1 antibody is PANK1 Antibody (B-9): sc-390865.