Date published: 2026-5-5

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pan nRNP Antibody (2Q2237): sc-71835

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  • pan nRNP Antibody (2Q2237) is a mouse monoclonal IgM pan nRNP antibody provided at 100 µg/ml
  • raised against nuclei from a leukemia cell line of human origin
  • recommended for detection of pan nRNP of human origin by IF, IHC(P) and FCM
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for pan nRNP Antibody (2Q2237). This work is in progress.
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    pan nRNP Antibody (2Q2237) is a mouse monoclonal IgM antibody that detects pan nRNP protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). pan nRNP (2Q2237) antibody is available as the non-conjugated format, providing researchers with a reliable tool for studying the complex role of ribonucleoproteins in various biological processes. Ribonucleoproteins (RNPs) are essential components of the cell nucleus, forming 20-80 nm electron-dense structures that play a critical role in RNA processing and regulation. RNPs localization within the nucleus is vital, as RNPs are involved in the assembly and maturation of ribonucleoprotein complexes, which are crucial for RNA synthesis and modification. RNPs presence in the nucleolus highlights their importance in ribosome biogenesis and overall regulation of gene expression. Furthermore, accumulation of anti-nuclear antibodies, including those targeting RNPs, is a hallmark of several autoimmune disorders, such as lupus erythematosus, Sjögren′s syndrome, autoimmune hepatitis, dermatomyositis, rheumatoid arthritis, and scleroderma. By utilizing pan nRNP (2Q2237) monoclonal antibody, researchers can gain insights into the pathophysiology of these diseases and underlying mechanisms of immune response, making pan nRNP (2Q2237) antibody an invaluable asset in both clinical and research settings.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    pan nRNP Antibody (2Q2237) References:

    1. Assessment of cell cycle-associated antigen expression using multiparameter flow cytometry and antibody-acridine orange sequential staining.  |  Bauer, KD., et al. 1986. J Histochem Cytochem. 34: 245-50. PMID: 2418102
    2. HLA-DR4 and Gm(1,3;5,21) are associated with U1-nRNP antibody positive connective tissue disease.  |  Genth, E., et al. 1987. Ann Rheum Dis. 46: 189-96. PMID: 2953314
    3. Quantitative analysis of a nuclear antigen in interphase and mitotic cells.  |  Clevenger, CV., et al. 1987. Cytometry. 8: 280-6. PMID: 3297564
    4. Simultaneous nuclear antigen and DNA content quantitation using paraffin-embedded colonic tissue and multiparameter flow cytometry.  |  Bauer, KD., et al. 1986. Cancer Res. 46: 2428-34. PMID: 3516382
    5. Idiopathic pulmonary fibrosis associated with high-titer antibodies against nuclear ribonucleoprotein (nRNP): report of 3 cases.  |  Pluss, JL. and West, SG. 1986. J Am Osteopath Assoc. 86: 735-42. PMID: 3539896
    6. A method for simultaneous nuclear immunofluorescence and DNA content quantitation using monoclonal antibodies and flow cytometry.  |  Clevenger, CV., et al. 1985. Cytometry. 6: 208-14. PMID: 3888556

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    pan nRNP Antibody (2Q2237)

    sc-71835
    100 µg/ml
    $322.00