P. falciparum infected RBCs Antibody (IIIB6): sc-80906

P. falciparum infected RBCs Antibody (IIIB6) is a mouse monoclonal IgM antibody that detects P. falciparum infected RBCs protein of Plasmodium falciparum origin by immunofluorescence (IF). P. falciparum infected RBCs (IIIB6) antibody is available in a non-conjugated form, specifically designed for detecting erythrocytes infected with Plasmodium falciparum at all stages of its life cycle. Understanding P. falciparum infected red blood cells is crucial for parasite survival and propagation within the human host. Once Plasmodium falciparum invades red blood cells, a complex life cycle begins, including asexual reproduction, leading to host cell destruction and release of new parasites into the bloodstream. This process contributes to malaria symptoms, such as anemia and fever, while playing a pivotal role in severe malaria pathogenesis, which can cause life-threatening complications. Using P. falciparum infected RBCs (IIIB6) monoclonal antibody in research helps scientists gain valuable insights into parasite-host cell interactions, advancing the development of targeted therapies and vaccines against malaria, a significant global health challenge.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

P. falciparum infected RBCs Antibody (IIIB6) References:

1. Genome sequence of the human malaria parasite Plasmodium falciparum.  |  Gardner, MJ., et al. 2002. Nature. 419: 498-511. PMID: 12368864
2. Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum.  |  Foth, BJ., et al. 2003. Science. 299: 705-8. PMID: 12560551
3. Early origin and recent expansion of Plasmodium falciparum.  |  Joy, DA., et al. 2003. Science. 300: 318-21. PMID: 12690197
4. The origin of malaria: mixed messages from genetic diversity.  |  Hartl, DL. 2004. Nat Rev Microbiol. 2: 15-22. PMID: 15035005
5. The global distribution of clinical episodes of Plasmodium falciparum malaria.  |  Snow, RW., et al. 2005. Nature. 434: 214-7. PMID: 15759000
6. Switching Plasmodium falciparum genes on and off for erythrocyte invasion.  |  Cortés, A. 2008. Trends Parasitol. 24: 517-24. PMID: 18805736
7. Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria.  |  Leoratti, FM., et al. 2008. Malar J. 7: 186. PMID: 18816374
8. Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene.  |  Escalante, AA., et al. 1995. Mol Biol Evol. 12: 616-26. PMID: 7659017
9. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.  |  Gardner, MJ., et al. 1998. Science. 282: 1126-32. PMID: 9804551

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P. falciparum infected RBCs Antibody (IIIB6) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P. falciparum infected RBCs Antibody (IIIB6) Specifications

Alternate Product Name: P. falciparum infected RBCs

Product Clone Name: IIIB6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Plasmodium falciparum conjugated with albumin

Epitope Species: mouse

Product Reactivity/Detection: erythrocytes infected with Plasmodium falciparum (all stages)

Species Reactivity/Detection: Plasmodium falciparum

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for P. falciparum infected RBCs Antibody (IIIB6): N/A