Date published: 2026-7-29

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Olivetolic Acid (CAS 491-72-5)

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Alternate Names:
6-Pentyl-β-resorcylic Acid; 2,4-Dihydroxy-6-pentylbenzoic Acid; Allazetolcarboxylic Acid
Application:
Olivetolic Acid is a key metabolic intermediate in the biosynthesis of cannabinoids
CAS Number:
491-72-5
Molecular Weight:
224.25
Molecular Formula:
C12H16O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Olivetolic acid, a naturally occurring organic compound, plays a pivotal role in the biosynthetic pathways of various cannabinoid compounds, serving as a precursor in the synthesis of cannabigerolic acid (CBGA), a foundational building block for many cannabinoids. Its significance extends into research, particularly in the field of plant biochemistry and genetics, where it is used to understand the complex processes underlying cannabinoid synthesis and regulation within cannabis plants. By studying olivetolic acid and its enzymatic interactions, specifically with geranyl pyrophosphate via the action of the enzyme olivetolic acid cyclase, scientists are able to elucidate the mechanisms through which cannabinoids are formed, paving the way for advancements in the manipulation of cannabinoid profiles for research purposes. This compound′s role is not only foundational in the natural production of cannabinoids but also instrumental in facilitating a deeper understanding of plant secondary metabolism, offering insights into the genetic engineering of cannabis strains to optimize the production of specific cannabinoids for research into their myriad potential applications.


Olivetolic Acid (CAS 491-72-5) References

  1. Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses.  |  Fellermeier, M., et al. 2001. Eur J Biochem. 268: 1596-604. PMID: 11248677
  2. Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa.  |  Raharjo, TJ., et al. 2004. Plant Physiol Biochem. 42: 291-7. PMID: 15120113
  3. Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes.  |  Sirikantaramas, S., et al. 2005. Plant Cell Physiol. 46: 1578-82. PMID: 16024552
  4. PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants.  |  Flores-Sanchez, IJ. and Verpoorte, R. 2008. Plant Cell Physiol. 49: 1767-82. PMID: 18854334
  5. Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.  |  Taura, F., et al. 2009. FEBS Lett. 583: 2061-6. PMID: 19454282
  6. Cannabinoids act as necrosis-inducing factors in Cannabis sativa.  |  Shoyama, Y., et al. 2008. Plant Signal Behav. 3: 1111-2. PMID: 19704450
  7. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.  |  Gagne, SJ., et al. 2012. Proc Natl Acad Sci U S A. 109: 12811-6. PMID: 22802619
  8. Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum.  |  Oettl, SK., et al. 2013. PLoS One. 8: e76929. PMID: 24130812
  9. Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa.  |  Yang, X., et al. 2016. FEBS J. 283: 1088-106. PMID: 26783002
  10. Crystal structure of olivetolic acid: a natural product from Cetrelia sanguinea (Schaer.).  |  Ismed, F., et al. 2016. Acta Crystallogr E Crystallogr Commun. 72: 1587-1589. PMID: 27840714
  11. Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli.  |  Tan, Z., et al. 2018. ACS Synth Biol. 7: 1886-1896. PMID: 29976061
  12. High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway.  |  Okorafor, IC., et al. 2021. ACS Synth Biol. 10: 2159-2166. PMID: 34415146
  13. Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome.  |  Anderson, LL., et al. 2022. J Cannabis Res. 4: 2. PMID: 34980287
  14. Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica.  |  Ma, J., et al. 2022. Commun Biol. 5: 1239. PMID: 36371560
  15. Novel insights into the antibacterial activities of cannabinoid biosynthetic intermediate, olivetolic acid, and its alkyl-chain derivatives.  |  Lee, YE., et al. 2023. J Nat Med. 77: 298-305. PMID: 36572832

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Olivetolic Acid, 100 mg

sc-484998
100 mg
$312.00

Olivetolic Acid, 1 g

sc-484998A
1 g
$1914.00

Olivetolic Acid, 5 g

sc-484998B
5 g
$8677.00

Olivetolic Acid, 10 g

sc-484998C
10 g
$14045.00

Olivetolic Acid, 50 g

sc-484998D
50 g
$65857.00