oligophrenin-1 Antibody (F-3): sc-376037

Oligophrenin-1 Antibody (F-3) is a mouse monoclonal IgG2a antibody that detects oligophrenin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oligophrenin-1 plays a crucial role as a RhoGAP protein, stimulating the hydrolysis of GTP bound to Rho subfamily members, which is essential for regulating various cellular processes including cell migration, morphogenesis, and axon outgrowth. Anti-oligophrenin-1 antibody (F-3) influences the dynamics of the cytoskeleton and cellular signaling pathways that are vital for proper neuronal connectivity and plasticity. By facilitating GTP hydrolysis, oligophrenin-1 helps maintain the balance between active and inactive Rho proteins, thereby ensuring that cellular responses to external stimuli are appropriately regulated. Oligophrenin-1 (F-3) antibody serves as an invaluable tool for researchers investigating the intricate roles of Rho GTPases in health and disease.

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oligophrenin-1 Antibody (F-3) References:

1. Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia.  |  Bergmann, C., et al. 2003. Brain. 126: 1537-44. PMID: 12805098
2. Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia.  |  Zanni, G., et al. 2005. Neurology. 65: 1364-9. PMID: 16221952
3. Association of syndromic mental retardation with an Xq12q13.1 duplication encompassing the oligophrenin 1 gene.  |  Bedeschi, MF., et al. 2008. Am J Med Genet A. 146A: 1718-24. PMID: 18512229
4. The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.  |  Nadif Kasri, N., et al. 2009. Genes Dev. 23: 1289-302. PMID: 19487570
5. Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels.  |  Sel, S., et al. 2012. Gene Expr Patterns. 12: 63-7. PMID: 22119667
6. Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation.  |  Bleijerveld, OB., et al. 2013. Arterioscler Thromb Vasc Biol. 33: 1538-43. PMID: 23619296
7. Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development.  |  Barresi, S., et al. 2014. PLoS One. 9: e91351. PMID: 24637888
8. Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.  |  Meziane, H., et al. 2016. Hum Mol Genet. 25: 2314-2323. PMID: 27146843
9. Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.  |  Redolfi, N., et al. 2016. Hum Mol Genet. 25: 5198-5211. PMID: 27742778
10. Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1.  |  Cresto, N., et al. 2022. Cells. 11: PMID: 35563851

The preferred oligophrenin-1 antibody is oligophrenin-1 Antibody (A-12): sc-374330.