Okadaic Acid Antibody (7E1): sc-101359

Okadaic Acid Antibody (7E1) is a mouse monoclonal IgG1 antibody that detects Okadaic Acid protein in non-species specific samples by enzyme-linked immunosorbent assay (ELISA). Anti-Okadaic Acid antibody (7E1) is available as a non-conjugated format. Okadaic Acid (OA) is a potent fat-soluble toxin primarily found in bivalves, such as clams, scallops, oysters, and mussels, which can accumulate and pose significant health risks to humans through contaminated shellfish consumption. Okadaic Acid functions as a phosphatase inhibitor, disrupting normal cellular signaling by preventing protein phosphorylation within intestinal cells. This disruption leads to increased intestinal epithelium permeability to water, resulting in severe dehydration and diarrhetic shellfish poisoning (DSP) symptoms, including incapacitating diarrhea, nausea, vomiting, abdominal cramps, and chills. Okadaic Acid has been shown to elevate nerve growth factor (NGF) expression, which may protect cells from programmed cell death (apoptosis) and promote abnormal cell proliferation, potentially contributing to oncogenesis. These effects underscore the critical need for accurate detection and monitoring of Okadaic Acid in seafood products to safeguard public health.

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Okadaic Acid Antibody (7E1) References:

1. Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor.  |  Dounay, AB. and Forsyth, CJ. 2002. Curr Med Chem. 9: 1939-80. PMID: 12369865
2. Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells.  |  Messner, DJ., et al. 2006. J Cell Biochem. 99: 241-55. PMID: 16598789
3. Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons.  |  Yoon, SY., et al. 2008. Neurosci Lett. 437: 111-5. PMID: 18448253
4. The cytotoxicity and genotoxicity of okadaic acid are cell-line dependent.  |  Souid-Mensi, G., et al. 2008. Toxicon. 51: 1338-44. PMID: 18538364
5. Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis.  |  Ahn, KH., et al. 2009. Neurosci Lett. 449: 93-7. PMID: 19000740
6. Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.  |  Vale, C. and Botana, LM. 2008. FEBS J. 275: 6060-6. PMID: 19016863
7. The phosphatase inhibitor, okadaic acid, strongly protects primary rat cortical neurons from lethal oxygen-glucose deprivation.  |  Atkinson, T., et al. 2009. Biochem Biophys Res Commun. 378: 394-8. PMID: 19026614
8. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens.  |  Yi, KD., et al. 2009. J Neurochem. 108: 732-40. PMID: 19054278
9. Okadaic acid promotes angiogenesis via activation of hypoxia-inducible factor-1.  |  Kim, YS., et al. 2009. Cancer Lett. 276: 102-8. PMID: 19054610
10. Okadaic acid: a new probe for the study of cellular regulation.  |  Cohen, P., et al. 1990. Trends Biochem Sci. 15: 98-102. PMID: 2158158
11. The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers.  |  Fujiki, H., et al. 2018. J Cancer Res Clin Oncol. 144: 2339-2349. PMID: 30341686
12. Okadaic acid (OA): Toxicity, detection and detoxification.  |  Fu, LL., et al. 2019. Toxicon. 160: 1-7. PMID: 30639658