OAT1 Antibody (1F2): sc-293323
- OAT1 Antibody (1F2) is a mouse monoclonal IgG1 κ OAT1 antibody provided at 100 µg/ml
- raised against amino acids 451-550 of OAT1 of human origin
- recommended for detection of OAT1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OAT1 Antibody (1F2). This work is in progress.
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OAT1 Antibody (1F2) is a mouse monoclonal IgG1 kappa light chain antibody that detects OAT1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-OAT1 antibody (1F2) is available as a non-conjugated format. OAT1 protein, also known as organic anion transporter 1, plays a crucial role in renal excretion of various endogenous and exogenous organic anions, which is vital for maintaining metabolic homeostasis and detoxifying harmful substances in the body. This 563 amino acid protein is predominantly localized to the basolateral membrane of renal proximal tubules, where OAT1 facilitates transport of organic anions, such as benzylpenicillin and cimetidine, thereby contributing to elimination of potentially toxic compounds from the bloodstream. OAT1 operates as an organic anion exchanger, coupling uptake of one organic anion with efflux of an endogenous dicarboxylic acid, such as α-ketoglutarate, which is essential for maintaining balance of these metabolites in kidneys. Expression of OAT1 is regulated through alternative splicing, resulting in generation of four distinct isoforms, which may have different functional properties and regulatory mechanisms. Anti-OAT1 antibody (1F2) is an invaluable tool for researchers studying physiological and pathological roles of OAT1 in renal function and drug metabolism.
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OAT1 Antibody (1F2) References:
- Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). | Race, JE., et al. 1999. Biochem Biophys Res Commun. 255: 508-14. PMID: 10049739
- Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. | Bahn, A., et al. 2000. Biochem Biophys Res Commun. 275: 623-30. PMID: 10964714
- Isolation of a family of organic anion transporters from human liver and kidney. | Sun, W., et al. 2001. Biochem Biophys Res Commun. 283: 417-22. PMID: 11327718
- Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. | Vallon, V., et al. 2008. Am J Physiol Renal Physiol. 294: F867-73. PMID: 18216144
- Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney. | Ogasawara, K., et al. 2008. J Hum Genet. 53: 607-614. PMID: 18414781
- Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury. | Zhang, R., et al. 2008. Am J Nephrol. 28: 772-83. PMID: 18441523
- Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. | Chen, J., et al. 2008. Am J Physiol Renal Physiol. 295: F247-52. PMID: 18480179
- Interaction of imatinib with human organic ion carriers. | Hu, S., et al. 2008. Clin Cancer Res. 14: 3141-8. PMID: 18483382
- Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. | Lu, R., et al. 1999. Am J Physiol. 276: F295-303. PMID: 9950961
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OAT1 Antibody (1F2) | sc-293323 | 100 µg/ml | $322.00 |