Molecular structure of O-Desmethyl Metoprolol, CAS Number: 62572-94-5
O-Desmethyl Metoprolol (CAS 62572-94-5)
See product citations (3)
Alternate Names:
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneethanol;(±)-4-[2-Hydroxy-3-(isopropylamino)propoxy]phenylethyl Alcohol
Application:
O-Desmethyl Metoprolol is A metabolite of Metoprolol
CAS Number:
62572-94-5
Molecular Weight:
253.34
Molecular Formula:
C14H23NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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O-Desmethyl metoprolol, an active metabolite of metoprolol, exhibits potent inhibitory properties on beta-adrenergic receptors, effectively modulating their activity.research on metabolites like O-Desmethyl Metoprolol can also contribute to the field of forensic science. Understanding the metabolic pathways of substances can aid in the interpretation of toxicology reports. In kinetic studies, understanding the formation and activity of metabolites like O-Desmethyl Metoprolol can help in predicting chemical behavior, including absorption, distribution, metabolism, and excretion (ADME) profiles.
O-Desmethyl Metoprolol (CAS 62572-94-5) References
- Determination of metoprolol enantiomers in human urine by coupled achiral-chiral chromatography. | Kim, KH., et al. 2000. J Pharm Biomed Anal. 22: 377-84. PMID: 10719921
- Determination of metoprolol, and its four metabolites in dog plasma. | Fang, J., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 809: 9-14. PMID: 15282087
- Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. | Finn, RD., et al. 2008. J Biol Chem. 283: 31385-93. PMID: 18805792
- UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. | Baranowska, I., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 615-26. PMID: 21345747
- Electrochemistry of Canis familiaris cytochrome P450 2D15 with gold nanoparticles: An alternative to animal testing in drug discovery. | Rua, F., et al. 2015. Bioelectrochemistry. 105: 110-6. PMID: 26092534
- In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions. | Boily, MO., et al. 2015. Drug Metab Dispos. 43: 1960-5. PMID: 26438628
- An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS. | Borkar, RM., et al. 2016. Biomed Chromatogr. 30: 1556-72. PMID: 27006091
- Transformation of atenolol, metoprolol, and carbamazepine in soils: The identification, quantification, and stability of the transformation products and further implications for the environment. | Koba, O., et al. 2016. Environ Pollut. 218: 574-585. PMID: 27514306
- Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC-ESI-MS/MS. | Sharma, P., et al. 2014. J Pharm Anal. 4: 63-79. PMID: 29403869
- Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs. | Lennard, MS., et al. 1986. Biochem Pharmacol. 35: 2757-61. PMID: 2943287
- Metoprolol induces oxidative damage in common carp (Cyprinus carpio). | Martínez-Rodríguez, H., et al. 2018. Aquat Toxicol. 197: 122-135. PMID: 29482075
- Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats. | Bang, WS., et al. 2019. J Pharm Pharm Sci. 22: 98-111. PMID: 30786957
- Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems. | Paine, MJ., et al. 1996. Arch Biochem Biophys. 328: 143-50. PMID: 8638923
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-Desmethyl Metoprolol, 5 mg | sc-208119 | 5 mg | $344.00 | |||
O-Desmethyl Metoprolol, 10 mg | sc-208119A | 10 mg | $562.00 |