nucleoporin p62 Antibody (1B6): sc-101542
- nucleoporin p62 Antibody (1B6) is a rat monoclonal IgG2a, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of nucleoporin p62 of human origin
- recommended for detection of amino acids 180-300 of nucleoporin p62 of human origin by WB, IP, IF and ELISA; non cross-reactive with nucleoporin p62 of mouse origin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for nucleoporin p62 Antibody (1B6). This work is in progress.
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Nucleoporin p62 Antibody (1B6) is a rat monoclonal IgG2a antibody that detects nucleoporin p62 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nucleoporin p62 plays a crucial role in the nuclear transport system, acting as a key component of the nuclear pore complex that regulates the selective transport of proteins and RNA between the nucleus and cytoplasm. Strategic location within the nuclear envelope allows nucleoporin p62 to facilitate the docking of karyopherin complexes, which are essential for the import of proteins into the nucleus. Additionally, nucleoporin p62 is involved in the export of nascent mRNA strands, highlighting dual functionality in nucleocytoplasmic transport. The interaction of nucleoporin p62 with other proteins, such as nuclear transport factor 2 (NTF2), underscores importance in maintaining cellular homeostasis and regulating gene expression. Anti-nucleoporin p62 antibody (1B6) enables researchers to gain valuable insights into the mechanisms of nuclear transport and the implications of dysregulation in various diseases, including cancer and neurodegenerative disorders.
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nucleoporin p62 Antibody (1B6) References:
- Monitoring autophagic degradation of p62/SQSTM1. | Bjørkøy, G., et al. 2009. Methods Enzymol. 452: 181-97. PMID: 19200883
- p62 links autophagy and Nrf2 signaling. | Jiang, T., et al. 2015. Free Radic Biol Med. 88: 199-204. PMID: 26117325
- p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. | Liu, WJ., et al. 2016. Cell Mol Biol Lett. 21: 29. PMID: 28536631
- Regulation of selective autophagy: the p62/SQSTM1 paradigm. | Lamark, T., et al. 2017. Essays Biochem. 61: 609-624. PMID: 29233872
- Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. | Sun, D., et al. 2018. Cell Res. 28: 405-415. PMID: 29507397
- p62/SQSTM1 and Selective Autophagy in Cardiometabolic Diseases. | Jeong, SJ., et al. 2019. Antioxid Redox Signal. 31: 458-471. PMID: 30588824
- Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. | You, Z., et al. 2019. Nat Commun. 10: 5792. PMID: 31857589
- S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. | Huang, X., et al. 2023. Mol Cell. 83: 3485-3501.e11. PMID: 37802024
- Local membrane source gathering by p62 body drives autophagosome formation. | Feng, X., et al. 2023. Nat Commun. 14: 7338. PMID: 37957156
- A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements. | Martin, S., et al. 2024. Science. 385: eadj7446. PMID: 39208097
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nucleoporin p62 Antibody (1B6) | sc-101542 | 200 µg/ml | $322.00 |